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The hemodynamic effects of oral hydralazine were investigated in ten patients (nine in NYHA Class IV and one in Class III) with chronic refractory heart failure. With hemodynamic monitoring, adequate oral doses of hydralazine (50 or 75 mg) were determined and then administered every six hours. Hemodynamics were determined at 2-3, 6-8 and 24 hours on hydralazine therapy. Arterial pressure decreased slightly (5%) and systemic vascular resistance decreased significantly (42%). Cardiac and stroke volume index increased by 70 and 66%, respectively, without any significant change in heart rate, pulmonary capillary wedge or right atrial pressure. Hemodynamic improvement was associated with clinical improvement without a major complication. During the follow-up period of 3-7 months, seven of nine patients were in NYHA Class II and one in Class III. One other patient died suddenly six weeks after discharge. These findings suggest that hydralazine in an effective oral vasodilator for the treatment of refractory heart failure.
K Chatterjee, and
W W Parmley, and
B Massie, and
B Greenberg, and
J Werner, and
S Klausner, and
A Norman
June 1983,
The Journal of the Association of Physicians of India,
K Chatterjee, and
W W Parmley, and
B Massie, and
B Greenberg, and
J Werner, and
S Klausner, and
A Norman
January 1983,
European journal of clinical pharmacology,
K Chatterjee, and
W W Parmley, and
B Massie, and
B Greenberg, and
J Werner, and
S Klausner, and
A Norman
January 1985,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
K Chatterjee, and
W W Parmley, and
B Massie, and
B Greenberg, and
J Werner, and
S Klausner, and
A Norman
July 1983,
American heart journal,
K Chatterjee, and
W W Parmley, and
B Massie, and
B Greenberg, and
J Werner, and
S Klausner, and
A Norman
September 1984,
Lakartidningen,
K Chatterjee, and
W W Parmley, and
B Massie, and
B Greenberg, and
J Werner, and
S Klausner, and
A Norman
June 1980,
European heart journal,
K Chatterjee, and
W W Parmley, and
B Massie, and
B Greenberg, and
J Werner, and
S Klausner, and
A Norman
January 1980,
Cardiology,
K Chatterjee, and
W W Parmley, and
B Massie, and
B Greenberg, and
J Werner, and
S Klausner, and
A Norman
March 1980,
Clinical pharmacology and therapeutics,
K Chatterjee, and
W W Parmley, and
B Massie, and
B Greenberg, and
J Werner, and
S Klausner, and
A Norman
March 1981,
Circulation,
K Chatterjee, and
W W Parmley, and
B Massie, and
B Greenberg, and
J Werner, and
S Klausner, and
A Norman
March 1987,
Zhonghua nei ke za zhi,
