Biomaterial Database

Metabolic clearance and production rates of progesterone in non-pregnant and pregnant baboons (Papio papio). 1976

E D Albrecht, and J D Townsley

The metabolic clearance rate (MCR) of progesterone was examined in the baboon to determine whether the increased serum progesterone concentrations during gestation result from increased production or decreased clearance. MCR was determined by constant infusion of [3H]progesterone in 6 non-pregnant baboons and 13 pregnant animals, between 58 and 175 days gestation. Progesterone MCR (mean+/-SE) was significantly greater in pregnant (1316+/-105 1/day, p less than 0.025; 87.3 +/- 6.2 1/day/kg, p less than 0.01) than in non-pregnant animals (893 +/- 75 1/day; 53.1 +/- 3.5 1/day/kg). There was no correlation between progesterone MCR and gestational age. Mean (+/- SE) progesterone MCR was similar during the follicular (938+/-119 1/day; 58.8+/-3.8 1/day/kg) and luteal (802+/-78 1/day; 52.4+/-6.8 1/day/kg) phases of the menstrual cycle. Serum progesterone concentrations (mean +/- SE, determined by radioimmunoassay, were 11.3+/-1.2 ng/ml in pregnant animals and 5.9+/-2.2 ng/ml during the luteal phase of the menstrual cycle. The mean (+/- SE) calculated progesterone production rates (MCR X serum progesterone concentration) were 4.57+/-1.74 mg/day during the luteal phase of the menstrual cycle and 15.26+/-2.48 mg/day during the last two-thirds of gestation. Thus, increased serum progesterone concentrations in pregnant baboons reflect enhanced production rather than decreased clearance. This is analogous to humans, but contrasts with rhesus monkeys, in which production is not increased during pregnancy. The elevated baboon progesterone MCR, despite increased serum corticosteroid binding capacity, indicates that other factors such as changes in maternal metabolism may also be important in regulating progesterone clearance.

UI	MeSH Term	Description	Entries
D008183	Luteal Phase	The period in the MENSTRUAL CYCLE that follows OVULATION, characterized by the development of CORPUS LUTEUM, increase in PROGESTERONE production by the OVARY and secretion by the glandular epithelium of the ENDOMETRIUM. The luteal phase begins with ovulation and ends with the onset of MENSTRUATION.	Menstrual Cycle, Luteal Phase,Menstrual Cycle, Secretory Phase,Menstrual Secretory Phase,Postovulatory Phase,Phase, Luteal,Phase, Postovulatory,Secretory Phase, Menstrual
D008657	Metabolic Clearance Rate	Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.	Total Body Clearance Rate,Clearance Rate, Metabolic,Clearance Rates, Metabolic,Metabolic Clearance Rates,Rate, Metabolic Clearance,Rates, Metabolic Clearance
D010215	Papio	A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.	Baboons,Baboons, Savanna,Savanna Baboons,Baboon,Baboon, Savanna,Papios,Savanna Baboon
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011270	Pregnancy, Animal	The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.	Animal Pregnancies,Animal Pregnancy,Pregnancies, Animal
D011374	Progesterone	The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.	Pregnenedione,Progesterone, (13 alpha,17 alpha)-(+-)-Isomer,Progesterone, (17 alpha)-Isomer,Progesterone, (9 beta,10 alpha)-Isomer
D005260	Female		Females
D005498	Follicular Phase	The period of the MENSTRUAL CYCLE representing follicular growth, increase in ovarian estrogen (ESTROGENS) production, and epithelial proliferation of the ENDOMETRIUM. Follicular phase begins with the onset of MENSTRUATION and ends with OVULATION.	Menstrual Cycle, Follicular Phase,Menstrual Cycle, Proliferative Phase,Menstrual Proliferative Phase,Preovulatory Phase,Phase, Follicular,Phase, Menstrual Proliferative,Phase, Preovulatory,Proliferative Phase, Menstrual
D005865	Gestational Age	The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination.	Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia