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Changes in immunoglobulin class and subclass levels and the development of antitumor antibodies were assessed in normal and tumor-bearing mice challenged with Corynebacterium parvum. C. parvum administration resulted in a marked increase in certain immunoglobulin levels, especially Ig G2b, and in the development of antibodies reacting with syngeneic and allogeneic tumor cells. The serologic changes induced by C. parvum were dependent on the dose and route of administration; preliminary studies suggested that they may have been largly independent of T-cell function. These changes were suppressed by the administration of gold salts, which also inhibited the antitumor effect of C. parvum.
K James, and
N Willmott, and
I Milne, and
W H McBride
January 1977,
Developments in biological standardization,
K James, and
N Willmott, and
I Milne, and
W H McBride
September 1975,
British journal of cancer,
K James, and
N Willmott, and
I Milne, and
W H McBride
June 1977,
Immunology,
K James, and
N Willmott, and
I Milne, and
W H McBride
April 1985,
Antiviral research,
K James, and
N Willmott, and
I Milne, and
W H McBride
March 1977,
Journal of the National Cancer Institute,
K James, and
N Willmott, and
I Milne, and
W H McBride
January 1977,
Annales d'immunologie,
K James, and
N Willmott, and
I Milne, and
W H McBride
January 1978,
Advances in cancer research,
K James, and
N Willmott, and
I Milne, and
W H McBride
July 1987,
Clinical immunology and immunopathology,
K James, and
N Willmott, and
I Milne, and
W H McBride
February 1976,
Journal of the National Cancer Institute,
K James, and
N Willmott, and
I Milne, and
W H McBride
January 1976,
Cancer research,
