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In order to evaluate the interrelations of splenectomy, iron overload and cirrhosis, histologic specimens of liver and spleen were examined and correlated in 12 children with beta-thalassemia major. All patients had received blood transfusions since infancy. Correlations seemed to exist between splenic hemosiderosis and splenic weight, and between the latter and the age at time of splenectomy. All liver samples showed varying hemosiderosis, not correlated with the number of transfusions or the children's age. Irregular liver cirrhosis existed in three children, 7, 8, and 14 years after splenectomy. No cirrhosis existed in any of the children where the spleen was in situ. Splenectomy in children with thalassemia may carry the long-term risk of liver cirrhosis.
E Okon, and
I S Levij, and
E A Rachmilewitz
March 2015,
Blood cells, molecules & diseases,
E Okon, and
I S Levij, and
E A Rachmilewitz
June 1998,
Annals of the New York Academy of Sciences,
E Okon, and
I S Levij, and
E A Rachmilewitz
December 2006,
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine,
E Okon, and
I S Levij, and
E A Rachmilewitz
June 2015,
Open access Macedonian journal of medical sciences,
E Okon, and
I S Levij, and
E A Rachmilewitz
January 2014,
PloS one,
E Okon, and
I S Levij, and
E A Rachmilewitz
January 1993,
Bone marrow transplantation,
E Okon, and
I S Levij, and
E A Rachmilewitz
May 2009,
International journal of cardiology,
E Okon, and
I S Levij, and
E A Rachmilewitz
October 2008,
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,
E Okon, and
I S Levij, and
E A Rachmilewitz
April 2010,
Diabetology & metabolic syndrome,
E Okon, and
I S Levij, and
E A Rachmilewitz
May 2003,
Haematologica,
