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A new haemoglobin, Hb Helsinki, in which beta 82-Lys (EF6) is replaced by Met, was found in a Finnish family. It was associated with familial erythrocytosis, and the oxygen affinity of the blood was higher than normal. The oxygen equilibrium curves of purified Hb Helsinki and HbA from the same haemolysate have been determined under vaious conditions. "Stripped' Hb Helsinki was found to show normal cooperativity, slightly low oxygen affinity and a reduced Bohr effect at physiological pH. However, the organic phosphates, 2,3-diphosphoglycerate (2,3-DPG) and inositol hexaphosphate (IHP) had a very small effect on Hb Helsinki, and the 2,3-DPG binding constant of deoxygenated Hb Helsinki is close to that of oxyhaemoglobin A. Thus, the replacement of Lys by Met at position 82 dramatically changes the nature of the central cavity of the tetramer and the effect of 2,3-DPG on the respiratory function of the molecule.
E Ikkala, and
J Koskela, and
P Pikkarainen, and
E L Rahiala, and
M A El-Hazmi, and
K Nagai, and
A Lang, and
H Lehmann
May 2017,
Hemoglobin,
E Ikkala, and
J Koskela, and
P Pikkarainen, and
E L Rahiala, and
M A El-Hazmi, and
K Nagai, and
A Lang, and
H Lehmann
May 1996,
Hemoglobin,
E Ikkala, and
J Koskela, and
P Pikkarainen, and
E L Rahiala, and
M A El-Hazmi, and
K Nagai, and
A Lang, and
H Lehmann
January 2005,
Hemoglobin,
E Ikkala, and
J Koskela, and
P Pikkarainen, and
E L Rahiala, and
M A El-Hazmi, and
K Nagai, and
A Lang, and
H Lehmann
January 1982,
Hemoglobin,
E Ikkala, and
J Koskela, and
P Pikkarainen, and
E L Rahiala, and
M A El-Hazmi, and
K Nagai, and
A Lang, and
H Lehmann
January 1992,
Hemoglobin,
E Ikkala, and
J Koskela, and
P Pikkarainen, and
E L Rahiala, and
M A El-Hazmi, and
K Nagai, and
A Lang, and
H Lehmann
January 1992,
Hemoglobin,
E Ikkala, and
J Koskela, and
P Pikkarainen, and
E L Rahiala, and
M A El-Hazmi, and
K Nagai, and
A Lang, and
H Lehmann
January 1976,
Hemoglobin,
E Ikkala, and
J Koskela, and
P Pikkarainen, and
E L Rahiala, and
M A El-Hazmi, and
K Nagai, and
A Lang, and
H Lehmann
January 1974,
Annual review of medicine,
E Ikkala, and
J Koskela, and
P Pikkarainen, and
E L Rahiala, and
M A El-Hazmi, and
K Nagai, and
A Lang, and
H Lehmann
January 2021,
Hemoglobin,
E Ikkala, and
J Koskela, and
P Pikkarainen, and
E L Rahiala, and
M A El-Hazmi, and
K Nagai, and
A Lang, and
H Lehmann
January 1976,
Hemoglobin,
