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In order to assess fetal function at term, we have investigated parameters of thyroid hormone secretion and degradation in human amniotic fluid and in cord and maternal sera at delivery. The parameters measured included 3,3' L-diiodothyronine (3,3'T2), 3,3',5'-triiodothyronine (reverse T3), 3,3',5'-triiodothyronine (T3), thyroxine (T4), dialyzable T3 and T4, thyroxine binding globulin (TBG),and total iodine. The mean (+/- SE) 3,3'T2 concentrations in cord sera, amniotic fluid, and maternal sera were 20 +/- 1 ng/100 ml, 20 +/- 2 ng/100 ml,and 27 +/- 3 ng/100 ml, respectively. The normal range of this metabolite in the sera of non-pregnant adult subjects was 7 to 29 ng/100 ml. The mean (+/- SE) concentration of reverse T3 was higher in cord sera (315 +/- 16 ng/100 ml), amniotic fluid (82 +/- 25 ng/100 ml) and maternal sera (79 +/- 5 ng/100 ml) than in the sera of normal subjects (mean +/- 2 SD; 60 +/- 12 ng/100 ml). In amniotic fluid, T3, T4, and TBG were low, per cent dialyzable T3 and T4 were increased, and iodine concentrations were relatively normal in comparison to their respective serum levels in euthyroid adults. Since T3 and T4 were low in amniotic fluid our data indicate that measurements of 3,3'T2, reverse T3, or per cent dialyzable T3 and T4 in amniotic fluid would be the potentially most useful in establishing the diagnosis of congenital hypothyroidism before birth. In addition, these studies demonstrate that 3,3'T2 is normally present in the peripheral circulation and suggest that reverse T3 is the major source of 3,3'T2 in both amniotic fluid and cord blood.
K D Burman, and
J Read, and
R C Dimond, and
D Strum, and
F D Wright, and
W Patow, and
J M Earll, and
L Wartofsky
July 1977,
European journal of pediatrics,
K D Burman, and
J Read, and
R C Dimond, and
D Strum, and
F D Wright, and
W Patow, and
J M Earll, and
L Wartofsky
November 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
K D Burman, and
J Read, and
R C Dimond, and
D Strum, and
F D Wright, and
W Patow, and
J M Earll, and
L Wartofsky
November 1978,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
K D Burman, and
J Read, and
R C Dimond, and
D Strum, and
F D Wright, and
W Patow, and
J M Earll, and
L Wartofsky
February 1981,
Clinical endocrinology,
K D Burman, and
J Read, and
R C Dimond, and
D Strum, and
F D Wright, and
W Patow, and
J M Earll, and
L Wartofsky
June 1985,
Nihon Sanka Fujinka Gakkai zasshi,
K D Burman, and
J Read, and
R C Dimond, and
D Strum, and
F D Wright, and
W Patow, and
J M Earll, and
L Wartofsky
January 1982,
Methods in enzymology,
K D Burman, and
J Read, and
R C Dimond, and
D Strum, and
F D Wright, and
W Patow, and
J M Earll, and
L Wartofsky
November 1984,
Acta endocrinologica,
K D Burman, and
J Read, and
R C Dimond, and
D Strum, and
F D Wright, and
W Patow, and
J M Earll, and
L Wartofsky
August 1977,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
K D Burman, and
J Read, and
R C Dimond, and
D Strum, and
F D Wright, and
W Patow, and
J M Earll, and
L Wartofsky
January 1982,
Clinica chimica acta; international journal of clinical chemistry,
K D Burman, and
J Read, and
R C Dimond, and
D Strum, and
F D Wright, and
W Patow, and
J M Earll, and
L Wartofsky
April 1979,
Clinical endocrinology,
