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The T cell receptor (TCR) requirements in the pathogenesis of insulin-dependent diabetes were examined with transgenic NOD mice bearing nondisease-related TCR alpha and beta chains. In both TCR beta and TCR alpha beta transgenic NOD mice the beta chain transgene was expressed by > 98% of peripheral T cells. The alpha chain transgene was also highly expressed. Insulitis developed in both sets of transgenic animals with most of the lymphocytes in the lesion expressing the transgenic beta chain and with depletion of the endogenous TCR V beta genes. Nonetheless, NOD animals transgenic for TCR beta and TCR alpha beta developed diabetes similar to controls. Thus, skewing the TCR repertoire did not diminish autoimmune susceptibility in NOD mice.
M A Lipes, and
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G S Eisenbarth
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M A Lipes, and
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G S Eisenbarth
November 1985,
Nihon Sanka Fujinka Gakkai zasshi,
M A Lipes, and
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G Tanigawa, and
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G S Eisenbarth
May 2000,
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M A Lipes, and
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G S Eisenbarth
September 2001,
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M A Lipes, and
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G S Eisenbarth
January 1993,
Annals of clinical and laboratory science,
M A Lipes, and
A Rosenzweig, and
K N Tan, and
G Tanigawa, and
D Ladd, and
J G Seidman, and
G S Eisenbarth
December 1993,
Science (New York, N.Y.),
M A Lipes, and
A Rosenzweig, and
K N Tan, and
G Tanigawa, and
D Ladd, and
J G Seidman, and
G S Eisenbarth
December 1993,
Science (New York, N.Y.),
M A Lipes, and
A Rosenzweig, and
K N Tan, and
G Tanigawa, and
D Ladd, and
J G Seidman, and
G S Eisenbarth
November 1997,
The Journal of experimental medicine,
M A Lipes, and
A Rosenzweig, and
K N Tan, and
G Tanigawa, and
D Ladd, and
J G Seidman, and
G S Eisenbarth
December 1993,
Science (New York, N.Y.),
M A Lipes, and
A Rosenzweig, and
K N Tan, and
G Tanigawa, and
D Ladd, and
J G Seidman, and
G S Eisenbarth
August 1986,
Diabetes,
