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Using fluorescence in situ hybridization, the human alpha-fodrin gene (nonerythroid alpha spectrin, SPTAN1), a member of the spectrin gene superfamily, was mapped to 9q33-->q34. This locus is near the translocation breakpoint region in the Philadelphia (Ph1) chromosome, t(9;22)(q34;q11). In a human chronic myelogenous leukemia cell line with the Ph1 chromosome, K562, the alpha-fodrin gene mapped centromeric to the translocation breakpoint, indicating that the alpha-fodrin gene is not translocated to the Ph1 chromosome in this cell line.
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