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The aim of this study was to determine whether the circadian rhythm of ornithine decarboxylase (ODC) activity in rat small intestine is controlled by factors other than luminal nutrients. ODC activity in duodenal and jejunal mucosa of rats fed ad libitum was measured at four time points (0500, 1100, 1700, 2300 h; light period: 0800-2000 h). ODC activity in the jejunum increased in the dark period, which is when rats normally eat. In contrast, ODC activity in the duodenum began to increase at 1700 h, which is when rats do not normally eat, as indicated by the recorded feeding pattern. The increase in ODC activity in the duodenum at 1700 h, but not at other time points, was abolished by subdiaphragmatic vagotomy, whereas vagotomy had no effect on the feeding pattern of rats. Subdiaphragmatic vagotomy had no effect on ODC activity in the jejunum. ODC activity in the duodenum increased following glycoprivation of the central nervous system induced by infusion of 2-deoxyglucose into the third cerebroventricle. These results indicate that the increase in duodenal ODC activity at 1700 h is due to a signal from the upper brain structure through the vagal nerve and not to luminal nutrient factors.
J Tanaka, and
K Fujimoto, and
T Sakata, and
T Fujimoto, and
S Tsunada, and
R Iwakiri, and
M Yamaguchi, and
Y Okabe, and
H Yoshimatsu
March 1987,
Biulleten' eksperimental'noi biologii i meditsiny,
J Tanaka, and
K Fujimoto, and
T Sakata, and
T Fujimoto, and
S Tsunada, and
R Iwakiri, and
M Yamaguchi, and
Y Okabe, and
H Yoshimatsu
January 1986,
Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR,
J Tanaka, and
K Fujimoto, and
T Sakata, and
T Fujimoto, and
S Tsunada, and
R Iwakiri, and
M Yamaguchi, and
Y Okabe, and
H Yoshimatsu
January 1991,
Canadian journal of physiology and pharmacology,
J Tanaka, and
K Fujimoto, and
T Sakata, and
T Fujimoto, and
S Tsunada, and
R Iwakiri, and
M Yamaguchi, and
Y Okabe, and
H Yoshimatsu
March 1990,
Gan no rinsho. Japan journal of cancer clinics,
J Tanaka, and
K Fujimoto, and
T Sakata, and
T Fujimoto, and
S Tsunada, and
R Iwakiri, and
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Y Okabe, and
H Yoshimatsu
December 1992,
Cell biochemistry and function,
J Tanaka, and
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H Yoshimatsu
September 1992,
Canadian journal of physiology and pharmacology,
J Tanaka, and
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M Yamaguchi, and
Y Okabe, and
H Yoshimatsu
June 1977,
Biochemical and biophysical research communications,
J Tanaka, and
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T Fujimoto, and
S Tsunada, and
R Iwakiri, and
M Yamaguchi, and
Y Okabe, and
H Yoshimatsu
February 1978,
Biochemical and biophysical research communications,
J Tanaka, and
K Fujimoto, and
T Sakata, and
T Fujimoto, and
S Tsunada, and
R Iwakiri, and
M Yamaguchi, and
Y Okabe, and
H Yoshimatsu
October 1981,
European journal of pharmacology,
J Tanaka, and
K Fujimoto, and
T Sakata, and
T Fujimoto, and
S Tsunada, and
R Iwakiri, and
M Yamaguchi, and
Y Okabe, and
H Yoshimatsu
August 1986,
Japanese journal of cancer research : Gann,
