-transparent.png){kind=logo}
Recombinant rat CNTF (ciliary neurotrophic factor) at picomolar concentration prevents the death of P19 murine embryonic carcinoma cells that usually follows upon withdrawal of serum from the culture medium. For prolonged survival of P19 cells in serum-free medium, insulin must also be present. In the presence or absence of serum, CNTF stimulates the differentiation of P19 cells, inducing the formation of neurites and synthesis of neurofilament. The results of radioautographic studies with radioiodinated CNTF indicate the presence of high-affinity binding sites on P19 cells. Equilibration of P19 cells with [125I]CNTF followed by incubation with cross-linking reagents reveals evidence for at least two putative receptors of approximately 78 and approximately 167 kDa.
S K Gupta, and
A J Haggarty, and
S Carbonetto, and
R J Riopelle, and
P M Richardson, and
R J Dunn
February 1994,
Cell,
S K Gupta, and
A J Haggarty, and
S Carbonetto, and
R J Riopelle, and
P M Richardson, and
R J Dunn
May 2001,
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
S K Gupta, and
A J Haggarty, and
S Carbonetto, and
R J Riopelle, and
P M Richardson, and
R J Dunn
January 1996,
Perspectives on developmental neurobiology,
S K Gupta, and
A J Haggarty, and
S Carbonetto, and
R J Riopelle, and
P M Richardson, and
R J Dunn
November 1993,
Development (Cambridge, England),
S K Gupta, and
A J Haggarty, and
S Carbonetto, and
R J Riopelle, and
P M Richardson, and
R J Dunn
November 1987,
Proceedings of the National Academy of Sciences of the United States of America,
S K Gupta, and
A J Haggarty, and
S Carbonetto, and
R J Riopelle, and
P M Richardson, and
R J Dunn
December 1990,
Experimental neurology,
S K Gupta, and
A J Haggarty, and
S Carbonetto, and
R J Riopelle, and
P M Richardson, and
R J Dunn
September 2015,
Iranian journal of basic medical sciences,
S K Gupta, and
A J Haggarty, and
S Carbonetto, and
R J Riopelle, and
P M Richardson, and
R J Dunn
November 1994,
Journal of neurobiology,
S K Gupta, and
A J Haggarty, and
S Carbonetto, and
R J Riopelle, and
P M Richardson, and
R J Dunn
March 1991,
Science (New York, N.Y.),
S K Gupta, and
A J Haggarty, and
S Carbonetto, and
R J Riopelle, and
P M Richardson, and
R J Dunn
April 1995,
Journal of neurochemistry,
