Biomaterial Database

Doppler echocardiographic assessment of left ventricular diastolic function in patients with progressive systemic sclerosis. 1993

S Fujimoto, and T Kagoshima, and T Nakajima, and K Dohi

First Department of Internal Medicine, Nara Medical University, Japan.

To investigate the diastolic function of the left ventricle in patients with progressive systemic sclerosis (PSS), 13 patients with PSS (3 males and 10 females; group PSS) were examined by Doppler echocardiography. As a control 8 age-matched healthy volunteers (3 males and 5 females; group H) were also examined. Pulse-wave transmitral Doppler flow velocity curves were digitized and curves of the first derivatives were obtained. In group PSS, total left ventricular wall thickness and left atrial dimension were increased, the ratio between the left ventricular end-diastolic dimension and the left ventricular wall thickness was decreased, late peak diastolic filling was increased, isovolumic relaxation time was prolonged, compared with group H. The patients with left ventricular wall thickening out of proportion to left ventricular end-diastolic dimension had decreased early peak diastolic filling. We conclude that patients with PSS have deterioration of left ventricular diastolic function, and the diastolic function is severely disturbed in patients with left ventricular wall thickening out of proportion to left ventricular end-diastolic dimensions.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D003971	Diastole	Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.	Diastoles
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012595	Scleroderma, Systemic	A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.	Sclerosis, Systemic,Systemic Scleroderma,Systemic Sclerosis
D015150	Echocardiography, Doppler	Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.	Doppler Echocardiography,Echocardiography, Continuous Doppler,Echocardiography, Two-Dimensional Doppler,2-D Doppler Echocardiography,2D Doppler Echocardiography,Continuous Doppler Echocardiography,Doppler Echocardiography, 2-D,Doppler Echocardiography, 2D,Doppler Echocardiography, Continuous,Doppler Echocardiography, Two-Dimensional,Echocardiography, 2-D Doppler,Echocardiography, 2D Doppler,Two-Dimensional Doppler Echocardiography,2 D Doppler Echocardiography,Doppler Echocardiography, 2 D,Doppler Echocardiography, Two Dimensional,Echocardiography, 2 D Doppler,Echocardiography, Two Dimensional Doppler,Two Dimensional Doppler Echocardiography
D016277	Ventricular Function, Left	The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.	Left Ventricular Function,Function, Left Ventricular,Functions, Left Ventricular,Left Ventricular Functions,Ventricular Functions, Left
D017379	Hypertrophy, Left Ventricular	Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.	Left Ventricular Hypertrophy,Ventricular Hypertrophy, Left,Hypertrophies, Left Ventricular,Left Ventricular Hypertrophies,Ventricular Hypertrophies, Left