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The inactivation of the hypothalamic hormone by rat liver and kidney homogenates was studied, using specific radioimmunoassays for the measurement of thyrotropin releasing hormone, pGlu-His-Pro-NH2 (TRH), and for an analogous peptide, pGlu-His-Pro-OH(TRH-OH), which has been proposed as a major metabolite of TRH [NAIR et al., 1971]. The inactivation of TRH and the free acid was found to be rapid. Heat lability and saturation kinetics suggest the involvement of enzymatic processes. In liver homogenate, TRH-OH production from TRH was observed. The accumulation of TRH-OH was substantial in experiments employing near-saturation concentrations of TRH. The liver and kidney are ascribed as major sites for breakdown of TRH in vivo.
T J Visser, and
W Klootwijk, and
R Docter, and
G Hennemann
January 1990,
Journal of neurochemistry,
T J Visser, and
W Klootwijk, and
R Docter, and
G Hennemann
February 1976,
Nature,
T J Visser, and
W Klootwijk, and
R Docter, and
G Hennemann
January 1987,
Nature,
T J Visser, and
W Klootwijk, and
R Docter, and
G Hennemann
January 1970,
Endocrinology,
T J Visser, and
W Klootwijk, and
R Docter, and
G Hennemann
May 1994,
Molecular and cellular endocrinology,
T J Visser, and
W Klootwijk, and
R Docter, and
G Hennemann
April 1984,
Journal of neurochemistry,
T J Visser, and
W Klootwijk, and
R Docter, and
G Hennemann
February 1974,
Acta pharmaceutica Suecica,
T J Visser, and
W Klootwijk, and
R Docter, and
G Hennemann
October 1975,
Biochemical and biophysical research communications,
T J Visser, and
W Klootwijk, and
R Docter, and
G Hennemann
August 1992,
The Journal of biological chemistry,
T J Visser, and
W Klootwijk, and
R Docter, and
G Hennemann
January 1961,
Acta biologica et medica Germanica,
