[Diagnostic significance of cerebrospinal fluid IgG determination by radial immunodiffusion]. 1976

K Zimmermann, and H Krause, and E Linke

The concentration of immunoglobulin G in 455 cerebrospinal fluids has been determined. The results obtained are discussed together with the corresponding total protein and gamma-globulin values. Classification by seven constellations and their assignment to four groups of diseases (acute and inflammatory diseases, chronically inflammatory diseases, E. d., and tumors) allows valuable information to be obtained about the diagnostic significance of IgG determination in the cerebrospinal fluid. This is true especially of E. d. and also applies to an assessment of the activity of inflammatory processes. It is evident from the results of these studies that an evaluation of the IgG value is not possible without considering the total content of protein. The value found for the quotient (see article).

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D002493 Central Nervous System Diseases Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord. CNS Disease,Central Nervous System Disease,Central Nervous System Disorder,CNS Diseases,Central Nervous System Disorders
D002556 Cerebrospinal Fluid Proteins Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister's Clinical Neurology, 7th ed, p221) Proteins, Cerebrospinal Fluid,Fluid Proteins, Cerebrospinal
D004679 Encephalomyelitis A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature. Myeloencephalitis,Encephalomyelitis, Inflammatory,Inflammatory Encephalomyelitis,Myeloencephalitides
D005779 Immunodiffusion Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction. Gel Diffusion Tests,Diffusion Test, Gel,Diffusion Tests, Gel,Gel Diffusion Test,Immunodiffusions,Test, Gel Diffusion,Tests, Gel Diffusion
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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