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A case of B-CLL which was complicated by chronic renal failure due to leukaemic infiltration of the kidney is reported. Treatment with chlorambucil, prednisolone, and renal bed irradiation resulted in a substantial improvement in renal function which persisted until the the patient's death from marrow failure some eight years later. The temporal association between treatments and response suggested that renal bed radiotherapy had contributed to the improvement in renal function. This case is one of only two reported cases in which chronic renal failure due to CLL has been treated with radiotherapy. It is unique in that the renal response was shown histologically. Leukaemic infiltration of the kidney is common in CLL but, characteristically, is not associated with renal impairment. An improvement in renal function has been described in two patients with acute renal failure after chemotherapy.
J K Phillips, and
P S Bass, and
G Majumdar, and
D R Davies, and
N F Jones, and
T C Pearson
January 1990,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
J K Phillips, and
P S Bass, and
G Majumdar, and
D R Davies, and
N F Jones, and
T C Pearson
January 2015,
Case reports in medicine,
J K Phillips, and
P S Bass, and
G Majumdar, and
D R Davies, and
N F Jones, and
T C Pearson
April 2005,
International journal of clinical practice. Supplement,
J K Phillips, and
P S Bass, and
G Majumdar, and
D R Davies, and
N F Jones, and
T C Pearson
April 2009,
Clinical and experimental nephrology,
J K Phillips, and
P S Bass, and
G Majumdar, and
D R Davies, and
N F Jones, and
T C Pearson
August 1992,
The Netherlands journal of medicine,
J K Phillips, and
P S Bass, and
G Majumdar, and
D R Davies, and
N F Jones, and
T C Pearson
January 1986,
Acta haematologica,
J K Phillips, and
P S Bass, and
G Majumdar, and
D R Davies, and
N F Jones, and
T C Pearson
January 2011,
Journal of surgical case reports,
J K Phillips, and
P S Bass, and
G Majumdar, and
D R Davies, and
N F Jones, and
T C Pearson
January 1990,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
J K Phillips, and
P S Bass, and
G Majumdar, and
D R Davies, and
N F Jones, and
T C Pearson
June 1998,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
J K Phillips, and
P S Bass, and
G Majumdar, and
D R Davies, and
N F Jones, and
T C Pearson
February 2008,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
