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Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal disorder thought to arise in a multipotent haemopoietic stem cell. A distinct clinical feature is a tendency to thrombosis, with a particular predilection for the hepatic veins (Budd-Chiari syndrome). We report here on two patients with PNH who developed hepatic vein thrombosis (HVT) and who were treated with tissue plasminogen activator (t-PA). Both patients had a marked clinical and radiological improvement following the t-PA treatment and remain well over 2 years and 6 years after the treatment. This method of thrombolysis for HVT occurring in PNH has only been reported in two previous patients with limited follow-up. We suggest that this therapy is a useful first-line treatment for PNH patients who develop HVT.
M F McMullin, and
P Hillmen, and
J Jackson, and
P Ganly, and
L Luzzatto
October 1968,
The Journal of obstetrics and gynaecology of the British Commonwealth,
M F McMullin, and
P Hillmen, and
J Jackson, and
P Ganly, and
L Luzzatto
January 1999,
Acta haematologica,
M F McMullin, and
P Hillmen, and
J Jackson, and
P Ganly, and
L Luzzatto
November 1993,
Australasian radiology,
M F McMullin, and
P Hillmen, and
J Jackson, and
P Ganly, and
L Luzzatto
July 1991,
Journal of the Indian Medical Association,
M F McMullin, and
P Hillmen, and
J Jackson, and
P Ganly, and
L Luzzatto
July 1980,
Scottish medical journal,
M F McMullin, and
P Hillmen, and
J Jackson, and
P Ganly, and
L Luzzatto
May 1992,
Journal of neurology, neurosurgery, and psychiatry,
M F McMullin, and
P Hillmen, and
J Jackson, and
P Ganly, and
L Luzzatto
January 1987,
Acta neurologica Belgica,
M F McMullin, and
P Hillmen, and
J Jackson, and
P Ganly, and
L Luzzatto
December 1986,
British journal of haematology,
M F McMullin, and
P Hillmen, and
J Jackson, and
P Ganly, and
L Luzzatto
June 1981,
British medical journal (Clinical research ed.),
M F McMullin, and
P Hillmen, and
J Jackson, and
P Ganly, and
L Luzzatto
June 1968,
The Ceylon medical journal,
