Biomaterial Database

IgG subclass concentrations and Gm allotypes in IgA-deficient and normal pregnant women. 1993

H Thom, and M J Main, and P Duffy, and P E Carter

Department of Child Health, Aberdeen University, UK.

IgG subclass concentrations were measured in the serum of 40 IgA-deficient (IgA concentration < 0.01 milligram) and 38 normal women in the second trimester of pregnancy. In the IgA-deficient group, 2 women were also deficient in IgG2 and IgG4, while a further 10 had very low concentrations of serum IgG4 only. These low IgG4 values were unrelated to the presence of anti-IgA antibodies. The incidence of low IgG4 values was significantly greater (p < 0.01) than in the control group where only 1 woman had low IgG4 and none had low IgG2. Mean values for total IgG, IgG1 and IgG3 were very significantly higher (p < 0.001) in the IgA-deficient group than in the control group. These differences were unrelated to Gm phenotype.

UI	MeSH Term	Description	Entries
D007074	Immunoglobulin G	The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.	Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007121	Immunocompetence	The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.	Competence, Immunologic,Immunologic Competence,Immunological Competence,Competence, Immunological
D007129	Immunoglobulin Gm Allotypes	Allelic variants of the gamma-immunoglobulin heavy chain (IMMUNOGLOBULIN GAMMA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN HEAVY CHAIN GENES.	Allotypes, Immunoglobulin Gm,Gm Allotypes,Ig Gm Allotypes,Allotype, Gm,Allotype, Ig Gm,Allotype, Immunoglobulin Gm,Allotypes, Gm,Allotypes, Ig Gm,Gm Allotype,Gm Allotype, Ig,Gm Allotype, Immunoglobulin,Gm Allotypes, Ig,Gm Allotypes, Immunoglobulin,Ig Gm Allotype,Immunoglobulin Gm Allotype
D008137	Longitudinal Studies	Studies in which variables relating to an individual or group of individuals are assessed over a period of time.	Bogalusa Heart Study,California Teachers Study,Framingham Heart Study,Jackson Heart Study,Longitudinal Survey,Tuskegee Syphilis Study,Bogalusa Heart Studies,California Teachers Studies,Framingham Heart Studies,Heart Studies, Bogalusa,Heart Studies, Framingham,Heart Studies, Jackson,Heart Study, Bogalusa,Heart Study, Framingham,Heart Study, Jackson,Jackson Heart Studies,Longitudinal Study,Longitudinal Surveys,Studies, Bogalusa Heart,Studies, California Teachers,Studies, Jackson Heart,Studies, Longitudinal,Study, Bogalusa Heart,Study, California Teachers,Study, Longitudinal,Survey, Longitudinal,Surveys, Longitudinal,Syphilis Studies, Tuskegee,Syphilis Study, Tuskegee,Teachers Studies, California,Teachers Study, California,Tuskegee Syphilis Studies
D010641	Phenotype	The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.	Phenotypes
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D017098	IgA Deficiency	A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN A.	Deficiency, IgA,Deficiencies, IgA,IgA Deficiencies