-transparent.png){kind=logo}
Transforming growth factor beta-1 (TGF-beta 1) has been proposed as a mediator of tumour growth in a number of tumours and cell lines including prostate, and in a recent study was shown to be up-regulated in the stroma of breast cancer tissue following treatment with the anti-oestrogen tamoxifen. Immunolocalisation of the intracellular form of TGF-beta 1 confirmed that the source of the stromal TGF-beta 1 was the peritumoral fibroblasts. We present here the results of a study in which five patients with hormonally unresponsive prostatic carcinoma and seven patients responding to a luteinising hormone-releasing hormone analogue had prostate biopsies taken before and during treatment. These were stained for TGF-beta expression prior to treatment and at either relapse or 3 months later respectively. Six of seven clinically responding tumours and three of five relapsed tumours showed up-regulation of extracellular TGF-beta 1, again primarily in the stroma, with no apparent up-regulation of intracellular TGF-beta 1, TGF-beta 2 or TGF-beta 3. These data illustrate that the epithelial growth inhibitor TGF-beta 1 can be induced by hormonal manipulation in prostate cancer in vivo, and may continue to be up-regulated even after relapse. This suggests that relapse of hormonally treated prostate cancer may be associated with a failure of the epithelium to respond to stromal TGF-beta 1.
G H Muir, and
A Butta, and
R J Shearer, and
C Fisher, and
D P Dearnaley, and
K C Flanders, and
M B Sporn, and
A A Colletta
February 1987,
Cell,
G H Muir, and
A Butta, and
R J Shearer, and
C Fisher, and
D P Dearnaley, and
K C Flanders, and
M B Sporn, and
A A Colletta
January 1995,
World journal of urology,
G H Muir, and
A Butta, and
R J Shearer, and
C Fisher, and
D P Dearnaley, and
K C Flanders, and
M B Sporn, and
A A Colletta
January 2005,
Cancer treatment and research,
G H Muir, and
A Butta, and
R J Shearer, and
C Fisher, and
D P Dearnaley, and
K C Flanders, and
M B Sporn, and
A A Colletta
December 1993,
The Journal of steroid biochemistry and molecular biology,
G H Muir, and
A Butta, and
R J Shearer, and
C Fisher, and
D P Dearnaley, and
K C Flanders, and
M B Sporn, and
A A Colletta
November 1994,
Endocrinology,
G H Muir, and
A Butta, and
R J Shearer, and
C Fisher, and
D P Dearnaley, and
K C Flanders, and
M B Sporn, and
A A Colletta
January 2008,
FEBS letters,
G H Muir, and
A Butta, and
R J Shearer, and
C Fisher, and
D P Dearnaley, and
K C Flanders, and
M B Sporn, and
A A Colletta
April 1993,
American journal of respiratory cell and molecular biology,
G H Muir, and
A Butta, and
R J Shearer, and
C Fisher, and
D P Dearnaley, and
K C Flanders, and
M B Sporn, and
A A Colletta
January 1997,
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research,
G H Muir, and
A Butta, and
R J Shearer, and
C Fisher, and
D P Dearnaley, and
K C Flanders, and
M B Sporn, and
A A Colletta
March 1989,
Molecular and cellular endocrinology,
G H Muir, and
A Butta, and
R J Shearer, and
C Fisher, and
D P Dearnaley, and
K C Flanders, and
M B Sporn, and
A A Colletta
March 2005,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
