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BACKGROUND Individual case reports have suggested an occasional association of lichen planus with internal malignancy. OBJECTIVE Our purpose was to describe five patients with a neoplastic disease in whom lichen planus developed. METHODS Serologic and immunopathologic studies were conducted. RESULTS No evidence of autoantibody production characteristic of paraneoplastic pemphigus was found, and antibodies reactive with basal cell keratinocytes were not detected. CONCLUSIONS Lichen planus may be rarely induced by neoplasia. A cell-mediated immune reaction possibly causes this phenomenon.
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