Biomaterial Database

Urinary magnesium excretion in steady-state sickle cell anaemia. 1993

A O Olukoga, and H O Adewoye, and R T Erasmus, and M A Adedoyin

Department of Chemical Pathology and Immunology, University of Ilorin, Nigeria.

Previous reports indicate that individuals with sickle cell anaemia may be magnesium deficient. The role of renal excretion of magnesium in the pathogenesis of this low magnesium status was investigated in 25 patients with sickle cell anaemia (sicklers) in the steady state and in 25 age- and sex-matched controls with haemoglobin genotype AA. The clearance, excretion fraction and excretion rates of magnesium were enhanced in the sicklers. These patients also had significantly lower erythrocyte and plasma magnesium concentrations than the controls. However expressed, urinary magnesium showed a significant positive correlation with plasma magnesium and a weak negative correlation with erythrocyte magnesium. Furthermore, a significant negative correlation was observed between erythrocyte and plasma magnesium in the sicklers. These results suggest that urinary disposal of magnesium in rates and amounts inappropriate to the body stores of the cation may be one of the mechanisms accounting for hypomagnesaemia and low erythrocyte magnesium content in patients with sickle cell anaemia.

UI	MeSH Term	Description	Entries
D008274	Magnesium	A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
D008297	Male		Males
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000755	Anemia, Sickle Cell	A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.	Hemoglobin S Disease,HbS Disease,Sickle Cell Anemia,Sickle Cell Disease,Sickle Cell Disorders,Sickling Disorder Due to Hemoglobin S,Anemias, Sickle Cell,Cell Disease, Sickle,Cell Diseases, Sickle,Cell Disorder, Sickle,Cell Disorders, Sickle,Disease, Hemoglobin S,Hemoglobin S Diseases,Sickle Cell Anemias,Sickle Cell Diseases,Sickle Cell Disorder
D016014	Linear Models	Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.	Linear Regression,Log-Linear Models,Models, Linear,Linear Model,Linear Regressions,Log Linear Models,Log-Linear Model,Model, Linear,Model, Log-Linear,Models, Log-Linear,Regression, Linear,Regressions, Linear