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Rab3A/Smg 25A, a small GTP-binding protein, is highly concentrated in presynapse of neurons and implicated in neurotransmitter release. We have recently identified a putative target protein for Rab3A, isolated its cDNA, and designated it as Rabphilin-3A. To examine whether Rabphilin-3A as well as Rab3A is localized at the sites of Ca(2+)-dependent exocytosis, we investigated here localization of Rabphilin-3A and Rab3A in comparison with the sites of exocytosis in the differentiated PC12 cells. Rabphilin-3A as well as Rab3A was highly concentrated at the tips of the neurites where Ca(2+)-dependent exocytosis took place. Inversely, neither Rabphilin-3A nor Rab3A was concentrated at the tips of the neurites where Ca(2+)-dependent exocytosis did not take place. These results suggest that Rabphilin-3A as well as Rab3A constitutes a part of the machinery necessary for neurotransmitter release.
K Wada, and
A Mizoguchi, and
K Kaibuchi, and
H Shirataki, and
C Ide, and
Y Takai
October 1993,
The Journal of biological chemistry,
K Wada, and
A Mizoguchi, and
K Kaibuchi, and
H Shirataki, and
C Ide, and
Y Takai
September 1994,
Biochemical and biophysical research communications,
K Wada, and
A Mizoguchi, and
K Kaibuchi, and
H Shirataki, and
C Ide, and
Y Takai
February 1996,
Biochemical and biophysical research communications,
K Wada, and
A Mizoguchi, and
K Kaibuchi, and
H Shirataki, and
C Ide, and
Y Takai
April 1993,
Molecular and cellular biology,
K Wada, and
A Mizoguchi, and
K Kaibuchi, and
H Shirataki, and
C Ide, and
Y Takai
July 1996,
Genes to cells : devoted to molecular & cellular mechanisms,
K Wada, and
A Mizoguchi, and
K Kaibuchi, and
H Shirataki, and
C Ide, and
Y Takai
September 1996,
Molecular and cellular biology,
K Wada, and
A Mizoguchi, and
K Kaibuchi, and
H Shirataki, and
C Ide, and
Y Takai
April 1994,
The Journal of biological chemistry,
K Wada, and
A Mizoguchi, and
K Kaibuchi, and
H Shirataki, and
C Ide, and
Y Takai
December 1994,
Biochemical and biophysical research communications,
K Wada, and
A Mizoguchi, and
K Kaibuchi, and
H Shirataki, and
C Ide, and
Y Takai
March 2018,
Endocrine journal,
K Wada, and
A Mizoguchi, and
K Kaibuchi, and
H Shirataki, and
C Ide, and
Y Takai
December 1993,
The Journal of biological chemistry,
