Studies were conducted on 20 crossbred lambs of 4-5 months old. Ten lambs were Nali x Corriedale cross (Hisardale) and the other 10 were Nali x Lohi cross (Munjal). Seven lambs each of both crossbreeds were infected with 10,000 infective larvae of Haemonchus contortus. Three lambs of each crossbreed served as uninfected controls. Clinicopathological examinations were done before and after infection and all the lambs were necropsied 28 days post-infection. The body weight gain, haemoglobin and packed cell volume were significantly lower in Hisardale lambs and the peripheral eosinophil count was significantly higher in Munjal lambs. Significant hypoalbuminaemia and hypoglobulinaemia, a sharp increase in albumin: globulin ratio; significantly higher faecal egg counts; adult worm counts; abomasal pH, volume, congestion and oedema were observed in Hisardale lambs as compared to Munjal lambs. Clinical signs of haemonchosis were more severe in Hisardale lambs and two of them died. Munjal lambs therefore seem less susceptible than Hisardale lambs to H. contortus infection.