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Herpes Simplex Encephalitis (HSE) appears to be underdiagnosed in India, though viral encephalitides constitutes an important entity with significant morbidity. With an upsurge in AIDS, HSE may perhaps emerge as an important opportunistic infection in future. We discuss the clinical features and laboratory evaluation of nine cases of HSE seen in the last 12 years at our center. Diagnosis was established by brain biopsy in one, virological studies in six and at autopsy in three. Immunocytochemically viral antigens could be localized in 4 biopsied/autopsied brain tissue and in CSF cells on a cytospin preparation in one. This has facilitated rapid diagnosis in our cases. Virus isolation was successful in two. Three subjects were treated with acyclovir and all survived with variable morbidity. Four patients expired and none of them had received any specific antiviral drugs. Rapid diagnosis and early treatment with acyclovir has been highlighted.
P Satishchandra, and
M Nandini, and
S K Shankar, and
T Vasudevarao, and
V Ravi, and
P K Shenoy, and
S Chatterjee, and
S Jain
April 1978,
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P Satishchandra, and
M Nandini, and
S K Shankar, and
T Vasudevarao, and
V Ravi, and
P K Shenoy, and
S Chatterjee, and
S Jain
November 1997,
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P Satishchandra, and
M Nandini, and
S K Shankar, and
T Vasudevarao, and
V Ravi, and
P K Shenoy, and
S Chatterjee, and
S Jain
October 1987,
Lakartidningen,
P Satishchandra, and
M Nandini, and
S K Shankar, and
T Vasudevarao, and
V Ravi, and
P K Shenoy, and
S Chatterjee, and
S Jain
April 1974,
Ugeskrift for laeger,
P Satishchandra, and
M Nandini, and
S K Shankar, and
T Vasudevarao, and
V Ravi, and
P K Shenoy, and
S Chatterjee, and
S Jain
September 1983,
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P Satishchandra, and
M Nandini, and
S K Shankar, and
T Vasudevarao, and
V Ravi, and
P K Shenoy, and
S Chatterjee, and
S Jain
February 1981,
The New England journal of medicine,
P Satishchandra, and
M Nandini, and
S K Shankar, and
T Vasudevarao, and
V Ravi, and
P K Shenoy, and
S Chatterjee, and
S Jain
January 2006,
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P Satishchandra, and
M Nandini, and
S K Shankar, and
T Vasudevarao, and
V Ravi, and
P K Shenoy, and
S Chatterjee, and
S Jain
January 2009,
BMJ case reports,
P Satishchandra, and
M Nandini, and
S K Shankar, and
T Vasudevarao, and
V Ravi, and
P K Shenoy, and
S Chatterjee, and
S Jain
January 1974,
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P Satishchandra, and
M Nandini, and
S K Shankar, and
T Vasudevarao, and
V Ravi, and
P K Shenoy, and
S Chatterjee, and
S Jain
August 1980,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
