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Renal proximal tubular sulfate reabsorption is mediated by brush border membrane Na+/sulfate-cotransport and basolateral Na(+)-independent sulfate transport. Injection of rat kidney cortex mRNA into Xenopus laevis oocytes induced Na(+)-dependent as well as Na(+)-independent sulfate transport. The inhibition pattern of Na(+)-dependent uptake coincided with that known for the brush border membrane; the inhibition pattern of Na(+)-independent uptake suggested that this activity could be related to the basolateral cell surface. By Northern blot hybridization of size-fractionated mRNA, we provide evidence that the Na(+)-dependent uptake is induced by an mRNA species related to a recently cloned cDNA encoding rat renal cortex Na+/SO4 cotransport (NaSi-1; Markovich, D., Forgo, J., Stange, G., Biber, J., and Murer, H. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 8073-8077); the Na(+)-independent sulfate transport activity seems to be related to an mRNA species encoding a rat liver Na(+)-independent sulfate transporter (Bissig, M., Hagenbuch, B., Stieger, B., Koller, T., and Meier, P. J. (1994) J. Biol. Chem. 269, 3017-3021). Hybrid depletion experiments using antisense oligonucleotides provided further evidence for the association of the expressed transport activities to NaSi-1 and sat-1, respectively.
D Markovich, and
M Bissig, and
V Sorribas, and
B Hagenbuch, and
P J Meier, and
H Murer
July 1990,
The Journal of biological chemistry,
D Markovich, and
M Bissig, and
V Sorribas, and
B Hagenbuch, and
P J Meier, and
H Murer
September 1992,
Molecular and cellular biochemistry,
D Markovich, and
M Bissig, and
V Sorribas, and
B Hagenbuch, and
P J Meier, and
H Murer
November 2000,
The Journal of membrane biology,
D Markovich, and
M Bissig, and
V Sorribas, and
B Hagenbuch, and
P J Meier, and
H Murer
July 1993,
The American journal of physiology,
D Markovich, and
M Bissig, and
V Sorribas, and
B Hagenbuch, and
P J Meier, and
H Murer
May 1990,
The Journal of biological chemistry,
D Markovich, and
M Bissig, and
V Sorribas, and
B Hagenbuch, and
P J Meier, and
H Murer
June 1994,
Pflugers Archiv : European journal of physiology,
D Markovich, and
M Bissig, and
V Sorribas, and
B Hagenbuch, and
P J Meier, and
H Murer
July 1995,
The Biochemical journal,
D Markovich, and
M Bissig, and
V Sorribas, and
B Hagenbuch, and
P J Meier, and
H Murer
February 1993,
The Journal of biological chemistry,
D Markovich, and
M Bissig, and
V Sorribas, and
B Hagenbuch, and
P J Meier, and
H Murer
January 2016,
Methods in enzymology,
D Markovich, and
M Bissig, and
V Sorribas, and
B Hagenbuch, and
P J Meier, and
H Murer
February 1992,
Biochimica et biophysica acta,
