Biomaterial Database

Giant cell fibroblastoma with dermatofibrosarcoma protuberans-like transformation. 1993

D A Perry, and L R Schultz, and L P Dehner

Department of Pathology and Surgery, Children's Hospital, Omaha, Nebraska.

A giant cell fibroblastoma (GCF) presented in the subcutis of the breast in a 13-month-old girl which recurred 6 years later as a dermal and subcutaneous neoplasm whose patterns were in part GCF and spindle cells with a storiform configuration resembling dermatofibrosarcoma protuberans (DFSP). The issue remains unsettled as to whether GCF is the juvenile variant of DFSP, but an argument about this relationship is supported circumstantially by a case such as ours.

UI	MeSH Term	Description	Entries
D007150	Immunohistochemistry	Histochemical localization of immunoreactive substances using labeled antibodies as reagents.	Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D009364	Neoplasm Recurrence, Local	The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.	Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D001943	Breast Neoplasms	Tumors or cancer of the human BREAST.	Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D005260	Female		Females
D005354	Fibrosarcoma	A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)	Fibrosarcomas
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012878	Skin Neoplasms	Tumors or cancer of the SKIN.	Cancer of Skin,Skin Cancer,Cancer of the Skin,Neoplasms, Skin,Cancer, Skin,Cancers, Skin,Neoplasm, Skin,Skin Cancers,Skin Neoplasm
D018223	Dermatofibrosarcoma	A sarcoma of the deep layers of the skin. The tumors are locally aggressive tends to recur but rarely metastatic. It can be classified into variants depending on the cell type tumors are derived from or by its characteristics: Pigmented variant from MELANIN-containing DERMAL DENDRITIC CELLS; Myxoid variant, myxoid STROMAL CELLS; Giant cell variant characterized by GIANT CELLS in the tumors; and Fibrosarcomatous variant chracterized by tumor areas histologically indistinguishable from FIBROSARCOMA.	Bednar Tumor,Bednar's Tumor,DFSP, Fibrosarcomatous,DFSP, Juvenile,DFSP, Myxoid,DFSP, Pigmented,Darier-Ferrand Tumor,Darier-Hoffmann Tumor,Dermatofibrosarcoma Protuberan,Dermatofibrosarcoma Protuberans, Familial,Dermatofibrosarcoma Protuberans, Fibrosarcomatous,Dermatofibrosarcoma Protuberans, Giant Cell,Dermatofibrosarcoma Protuberans, Myxoid,Dermatofibrosarcoma Protuberans, Pigmented,FS-DFSP,Familial Dermatofibrosarcoma Protuberans,Fibrosarcomatous Dermatofibrosarcoma Protuberans,Giant Cell Fibroblastoma,Giant Dermatofibrosarcoma Protuberans,Metastatic Dermatofibrosarcoma Protuberans,Bednars Tumor,Cell Fibroblastoma, Giant,Cell Fibroblastomas, Giant,DFSPs, Fibrosarcomatous,DFSPs, Juvenile,DFSPs, Myxoid,DFSPs, Pigmented,Darier Ferrand Tumor,Darier Hoffmann Tumor,Dermatofibrosarcoma Protuberan, Familial,Dermatofibrosarcoma Protuberan, Fibrosarcomatous,Dermatofibrosarcoma Protuberan, Giant,Dermatofibrosarcoma Protuberan, Metastatic,Dermatofibrosarcoma Protuberan, Myxoid,Dermatofibrosarcoma Protuberan, Pigmented,Dermatofibrosarcoma Protuberans,Dermatofibrosarcoma Protuberans, Giant,Dermatofibrosarcoma Protuberans, Metastatic,Dermatofibrosarcomas,Familial Dermatofibrosarcoma Protuberan,Fibroblastoma, Giant Cell,Fibroblastomas, Giant Cell,Fibrosarcomatous DFSP,Fibrosarcomatous DFSPs,Fibrosarcomatous Dermatofibrosarcoma Protuberan,Giant Cell Fibroblastomas,Giant Dermatofibrosarcoma Protuberan,Juvenile DFSP,Juvenile DFSPs,Metastatic Dermatofibrosarcoma Protuberan,Myxoid DFSP,Myxoid DFSPs,Myxoid Dermatofibrosarcoma Protuberan,Myxoid Dermatofibrosarcoma Protuberans,Pigmented DFSP,Pigmented DFSPs,Pigmented Dermatofibrosarcoma Protuberan,Pigmented Dermatofibrosarcoma Protuberans,Protuberan, Dermatofibrosarcoma,Protuberan, Familial Dermatofibrosarcoma,Protuberan, Fibrosarcomatous Dermatofibrosarcoma,Protuberan, Giant Dermatofibrosarcoma,Protuberan, Metastatic Dermatofibrosarcoma,Protuberan, Myxoid Dermatofibrosarcoma,Protuberan, Pigmented Dermatofibrosarcoma,Protuberans, Dermatofibrosarcoma,Protuberans, Familial Dermatofibrosarcoma,Protuberans, Fibrosarcomatous Dermatofibrosarcoma,Protuberans, Giant Dermatofibrosarcoma,Protuberans, Metastatic Dermatofibrosarcoma,Protuberans, Myxoid Dermatofibrosarcoma,Protuberans, Pigmented Dermatofibrosarcoma,Tumor, Bednar,Tumor, Bednar's,Tumor, Darier-Ferrand,Tumor, Darier-Hoffmann