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Swiss Webster mice were exposed to excess dietary aluminum (Al) (1000 micrograms Al/g diet, Al as Al lactate) from conception to 6 months of age. Splenic lymphocytes (10(6) per culture) were incubated for 24 hrs with concanavalin A (5 micrograms/ml). Concentrations of interleukin-2, interferon-gamma and tumor necrosis factor-alpha, as measured in supernatants via ELISA with monoclonal antibodies, were depressed in spleen cells from aluminum treated mice relative to controls. Experiments using the fluorescence activated cell sorter demonstrated a shift in T-cell populations from treated mice with a deficiency of CD4+ cells. These findings suggest a deficit in immune effector cell function after long term in vivo aluminum exposure.
M S Golub, and
P T Takeuchi, and
M E Gershwin, and
S H Yoshida
January 1989,
International archives of allergy and applied immunology,
M S Golub, and
P T Takeuchi, and
M E Gershwin, and
S H Yoshida
October 1993,
Metabolism: clinical and experimental,
M S Golub, and
P T Takeuchi, and
M E Gershwin, and
S H Yoshida
March 1978,
Transplantation proceedings,
M S Golub, and
P T Takeuchi, and
M E Gershwin, and
S H Yoshida
February 1997,
Mechanisms of ageing and development,
M S Golub, and
P T Takeuchi, and
M E Gershwin, and
S H Yoshida
January 1994,
Neurotoxicology and teratology,
M S Golub, and
P T Takeuchi, and
M E Gershwin, and
S H Yoshida
August 1989,
International journal for parasitology,
M S Golub, and
P T Takeuchi, and
M E Gershwin, and
S H Yoshida
August 1991,
European journal of immunology,
M S Golub, and
P T Takeuchi, and
M E Gershwin, and
S H Yoshida
April 1986,
Laboratory animal science,
M S Golub, and
P T Takeuchi, and
M E Gershwin, and
S H Yoshida
December 1990,
Immunology,
M S Golub, and
P T Takeuchi, and
M E Gershwin, and
S H Yoshida
July 1995,
Toxicology and applied pharmacology,
