BIOMAT Database Logo BIOMAT Database Logo

Dialysis-associated arthropathy: secondary ion mass spectrometry evidence of aluminum silicate in beta 2-microglobulin amyloid synovial tissue and articular cartilage. 1993

M Chaussidon, and P Netter, and M Kessler, and H Membre, and P Fener, and S Delons, and F Albarède
CRPG-CNRS, Vandoeuvre-les-Nancy, France.

The role of aluminum accumulation in articular tissues of patients affected by dialysis-associated arthropathy (DAA) is questioned. The aim of this work is to identify the nature of these aluminum accumulations by the use of secondary ion mass spectrometry (SIMS). Al/Si ratios of about 1, measured by SIMS, strongly suggest for the first time the presence of aluminum silicates and possibly aluminum hydroxides in amyloid synovial tissue and articular cartilage of 1 patient with DAA and aluminum intoxication. This is thermodynamically consistent with the total dissolved Al and Si contents and pH measured in the synovial fluids. These results are similar to the abnormal Al distribution recently found by SIMS in the forebrain of chronic renal dialysis patients and to the amorphous aluminum silicates identified in the core of senile plaques in Alzheimer's disease.

UI MeSH Term Description Entries
D007592 Joint Diseases Diseases involving the JOINTS. Arthropathies,Arthropathy,Joint Disease
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002358 Cartilage, Articular A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact. Articular Cartilage,Articular Cartilages,Cartilages, Articular
D005260 Female Females
D006435 Renal Dialysis Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION. Dialysis, Extracorporeal,Dialysis, Renal,Extracorporeal Dialysis,Hemodialysis,Dialyses, Extracorporeal,Dialyses, Renal,Extracorporeal Dialyses,Hemodialyses,Renal Dialyses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D000538 Aluminum Silicates Any of the numerous types of clay which contain varying proportions of Al2O3 and SiO2. They are made synthetically by heating aluminum fluoride at 1000-2000 degrees C with silica and water vapor. (From Hawley's Condensed Chemical Dictionary, 11th ed) Aluminum Silicate,Silicate, Aluminum,Silicates, Aluminum
D000682 Amyloid A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease. Amyloid Fibril,Amyloid Fibrils,Amyloid Substance,Fibril, Amyloid,Fibrils, Amyloid,Substance, Amyloid
D001613 beta 2-Microglobulin An 11-kDa protein associated with the outer membrane of many cells including LYMPHOCYTES. It is the small subunit of MHC CLASS I MOLECULES. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, CEREBROSPINAL FLUID, and urine of healthy individuals, and to a much greater degree in the urine and plasma of patients with tubular PROTEINURIA, renal failure, or kidney transplants. Thymotaxin,beta 2 Microglobulin

Related Publications

M Chaussidon, and P Netter, and M Kessler, and H Membre, and P Fener, and S Delons, and F Albarède
Synovial-fluid beta 2-microglobulin levels in dialysis arthropathy.
November 1986, The New England journal of medicine,
M Chaussidon, and P Netter, and M Kessler, and H Membre, and P Fener, and S Delons, and F Albarède
Highly sulphated glycosaminoglycans in articular cartilage and other tissues containing beta 2 microglobulin dialysis amyloid deposits.
January 1995, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
M Chaussidon, and P Netter, and M Kessler, and H Membre, and P Fener, and S Delons, and F Albarède
Dialysis arthropathy, amyloidosis and beta-2 microglobulin.
April 1987, Pediatric nephrology (Berlin, Germany),
M Chaussidon, and P Netter, and M Kessler, and H Membre, and P Fener, and S Delons, and F Albarède
Dialysis-related beta 2 microglobulin-amyloid arthropathy. Improvement of clinical symptoms after a switch of dialysis membranes.
March 1988, Clinical rheumatology,
M Chaussidon, and P Netter, and M Kessler, and H Membre, and P Fener, and S Delons, and F Albarède
Beta 2 microglobulin-derived amyloid in dialysis patients.
January 1989, Advances in experimental medicine and biology,
M Chaussidon, and P Netter, and M Kessler, and H Membre, and P Fener, and S Delons, and F Albarède
Synovial amyloid in chronic haemodialysis contains beta 2 microglobulin.
August 1987, Annals of the rheumatic diseases,
M Chaussidon, and P Netter, and M Kessler, and H Membre, and P Fener, and S Delons, and F Albarède
Beta-2-microglobulin origin of dialysis-related amyloid.
October 1987, Arthritis and rheumatism,
M Chaussidon, and P Netter, and M Kessler, and H Membre, and P Fener, and S Delons, and F Albarède
Dialysis arthropathy, beta 2-microglobulin and the effect of dialyser membrane.
January 1988, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
M Chaussidon, and P Netter, and M Kessler, and H Membre, and P Fener, and S Delons, and F Albarède
[Beta 2 microglobulin. 2: Dialysis-associated amyloidosis].
May 1988, Fortschritte der Medizin,
M Chaussidon, and P Netter, and M Kessler, and H Membre, and P Fener, and S Delons, and F Albarède
Dialysis-associated amyloidosis and beta-2-microglobulin.
January 1988, Contributions to nephrology,
Copied contents to your clipboard!