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Archival tissue biopsies of 17 cases of oral verrucous carcinoma were tested for human papillomaviruses by polymerase chain reaction followed by DNA slot-blot hybridization. Sections of the biopsies were also tested by in situ DNA hybridization with biotin-labeled probes for human papillomavirus types 6/11, 6/18, and 31/33/35. Using polymerase chain reaction, human papillomavirus DNA was detected in seven of 17 cases (41%). Slot-blot hybridization of the amplification products identified human papillomavirus type 6 in two cases, type 11 in four cases, and both types 6 and 11 in one case of oral verrucous carcinoma. In situ hybridization confirmed the presence of human papillomavirus type 6/11 DNA in tumor cell nuclei for each of the cases which tested positive by polymerase chain reaction and was negative in the remaining 10 cases. We conclude that human papillomavirus types 6 and 11 are frequently present in cases of oral verrucous carcinoma.
K R Shroyer, and
R O Greer, and
C A Fankhouser, and
W F McGuirt, and
R Marshall
December 1993,
Archives of otolaryngology--head & neck surgery,
K R Shroyer, and
R O Greer, and
C A Fankhouser, and
W F McGuirt, and
R Marshall
July 1992,
Nihon rinsho. Japanese journal of clinical medicine,
K R Shroyer, and
R O Greer, and
C A Fankhouser, and
W F McGuirt, and
R Marshall
November 1993,
Zhonghua yi xue za zhi,
K R Shroyer, and
R O Greer, and
C A Fankhouser, and
W F McGuirt, and
R Marshall
November 1992,
Cancer,
K R Shroyer, and
R O Greer, and
C A Fankhouser, and
W F McGuirt, and
R Marshall
February 1994,
The Laryngoscope,
K R Shroyer, and
R O Greer, and
C A Fankhouser, and
W F McGuirt, and
R Marshall
December 1995,
Cellular and molecular biology (Noisy-le-Grand, France),
K R Shroyer, and
R O Greer, and
C A Fankhouser, and
W F McGuirt, and
R Marshall
May 1996,
European journal of cancer (Oxford, England : 1990),
K R Shroyer, and
R O Greer, and
C A Fankhouser, and
W F McGuirt, and
R Marshall
April 1993,
The Laryngoscope,
K R Shroyer, and
R O Greer, and
C A Fankhouser, and
W F McGuirt, and
R Marshall
February 1997,
The American Journal of dermatopathology,
K R Shroyer, and
R O Greer, and
C A Fankhouser, and
W F McGuirt, and
R Marshall
June 1997,
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology,
