Biomaterial Database

Low molecular weight GTP-binding proteins: molecular switches regulating diverse cellular functions. 1994

A C Wagner, and J A Williams

Department of Physiology and Internal Medicine, University of Michigan, Ann Arbor 48109.

Low molecular weight GTP-binding proteins (LMWG proteins) form a family of proteins that shows homology with Ras, are 18-30 kDa in mass, and bind and hydrolyze GTP. They act as molecular switches, being active when binding GTP. Their activity is regulated by other proteins that influence the dissociation of GDP and the rate of GTP hydrolysis. Roles are emerging for these proteins in regulation of membrane fusion and cytoskeletal organization and growth. In the gastrointestinal tract, the best studied physiological processes that may be regulated by LMWG proteins are digestive enzyme and gastric acid secretion.

UI	MeSH Term	Description	Entries
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D008970	Molecular Weight	The sum of the weight of all the atoms in a molecule.	Molecular Weights,Weight, Molecular,Weights, Molecular
D004068	Digestive System Physiological Phenomena	Properties and processes of the DIGESTIVE SYSTEM as a whole or of any of its parts.	Digestive Physiology,Digestive System Processes,Digestive System Phenomena,Digestive System Phenomenon,Digestive System Physiological Concepts,Digestive System Physiological Phenomenon,Digestive System Physiology,Digestive System Process,Physiology, Digestive,Phenomena, Digestive System,Phenomenas, Digestive System,Phenomenon, Digestive System,Physiology, Digestive System,Process, Digestive System,Processes, Digestive System
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D019204	GTP-Binding Proteins	Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.	G-Proteins,GTP-Regulatory Proteins,Guanine Nucleotide Regulatory Proteins,G-Protein,GTP-Binding Protein,GTP-Regulatory Protein,Guanine Nucleotide Coupling Protein,G Protein,G Proteins,GTP Binding Protein,GTP Binding Proteins,GTP Regulatory Protein,GTP Regulatory Proteins,Protein, GTP-Binding,Protein, GTP-Regulatory,Proteins, GTP-Binding,Proteins, GTP-Regulatory
D020558	GTP Phosphohydrolases	Enzymes that hydrolyze GTP to GDP. EC 3.6.1.-.	GTPase,GTPases,Guanosine Triphosphate Phosphohydrolases,Guanosinetriphosphatases,GTP Phosphohydrolase,Phosphohydrolase, GTP,Phosphohydrolases, GTP,Phosphohydrolases, Guanosine Triphosphate,Triphosphate Phosphohydrolases, Guanosine