High-dose rate brachytherapy for carcinoma of the cervix. 1993

V E Arterbery
Division of Radiation Oncology, Johns Hopkins Oncology Center, Baltimore, MD 21287-8922.

Increasingly popular in Europe and Asia as the intracavitary component for cervical cancer radiotherapy, high-dose rate brachytherapy demonstrates certain advantages over historical low-dose rate treatments. High-dose rate intracavitary treatment improves radiation safety, lessens treatment times, allows for outpatient treatment regimens, and has improved packing and retraction techniques, which can decrease rectal and bladder doses. Although retrospective studies of high-dose rate treatment show survival rates comparable with those of historical low-dose rate intracavitary treatment, there have been few randomized, prospective studies to support the use of high-dose rate techniques. Low- and high-dose rate comparisons are further complicated by the lack of standardized fractionation schemes and dose prescriptions for high-dose rate treatment. Recent data showing decreased local control in advanced cervical cancer with the prolonged overall treatment time of low-dose rate treatment suggest the practical advantage of outpatient high-dose rate intracavitary brachytherapy, which uses fractionated regimens and shortens overall treatment times. Although high-dose rate treatment has not been shown to improve survival compared with low-dose rate treatment, its practical advantages may account for its increasing use.

UI MeSH Term Description Entries
D001918 Brachytherapy A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues. Curietherapy,Implant Radiotherapy,Plaque Therapy, Radioisotope,Radioisotope Brachytherapy,Radiotherapy, Interstitial,Radiotherapy, Intracavity,Radiotherapy, Surface,Brachytherapy, Radioisotope,Interstitial Radiotherapy,Intracavity Radiotherapy,Radioisotope Plaque Therapy,Radiotherapy, Implant,Surface Radiotherapy,Therapy, Radioisotope Plaque
D002583 Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX. Cancer of Cervix,Cancer of the Cervix,Cancer of the Uterine Cervix,Cervical Cancer,Cervical Neoplasms,Cervix Cancer,Cervix Neoplasms,Neoplasms, Cervical,Neoplasms, Cervix,Uterine Cervical Cancer,Cancer, Cervical,Cancer, Cervix,Cancer, Uterine Cervical,Cervical Cancer, Uterine,Cervical Cancers,Cervical Neoplasm,Cervical Neoplasm, Uterine,Cervix Neoplasm,Neoplasm, Cervix,Neoplasm, Uterine Cervical,Uterine Cervical Cancers,Uterine Cervical Neoplasm
D004307 Dose-Response Relationship, Radiation The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation. Dose Response Relationship, Radiation,Dose-Response Relationships, Radiation,Radiation Dose-Response Relationship,Radiation Dose-Response Relationships,Relationship, Radiation Dose-Response,Relationships, Radiation Dose-Response
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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