BIOMAT Database Logo BIOMAT Database Logo

Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in northern India. 1993

N K Mehra, and I Pande, and V Taneja, and S S Uppal, and S P Saxena, and A Kumar, and A N Malaviya
Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi.

Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.

UI MeSH Term Description Entries
D007194 India A country in southern Asia, bordering the Arabian Sea and the Bay of Bengal, between Burma and Pakistan. The capitol is New Delhi. Republic of India
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008285 Major Histocompatibility Complex The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement. Histocompatibility Complex,Complex, Histocompatibility,Complex, Major Histocompatibility,Complices, Histocompatibility,Complices, Major Histocompatibility,Histocompatibility Complex, Major,Histocompatibility Complices,Histocompatibility Complices, Major,Major Histocompatibility Complices
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005787 Gene Frequency The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION. Allele Frequency,Genetic Equilibrium,Equilibrium, Genetic,Allele Frequencies,Frequencies, Allele,Frequencies, Gene,Frequency, Allele,Frequency, Gene,Gene Frequencies
D006239 Haplotypes The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX. Haplotype
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

N K Mehra, and I Pande, and V Taneja, and S S Uppal, and S P Saxena, and A Kumar, and A N Malaviya
Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus.
October 1990, Arthritis and rheumatism,
N K Mehra, and I Pande, and V Taneja, and S S Uppal, and S P Saxena, and A Kumar, and A N Malaviya
Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in southern Chinese.
June 1992, Arthritis and rheumatism,
N K Mehra, and I Pande, and V Taneja, and S S Uppal, and S P Saxena, and A Kumar, and A N Malaviya
Major histocompatibility complex genes in systemic lupus erythematosus, Sjögren's syndrome, and polymyositis.
December 1988, The American journal of medicine,
N K Mehra, and I Pande, and V Taneja, and S S Uppal, and S P Saxena, and A Kumar, and A N Malaviya
Major histocompatibility complex associations with systemic lupus erythematosus.
December 1988, The American journal of medicine,
N K Mehra, and I Pande, and V Taneja, and S S Uppal, and S P Saxena, and A Kumar, and A N Malaviya
Major histocompatibility complex extended haplotypes in systemic lupus erythematosus.
January 1988, Disease markers,
N K Mehra, and I Pande, and V Taneja, and S S Uppal, and S P Saxena, and A Kumar, and A N Malaviya
DNA polymorphism of major histocompatibility complex class II and class III genes in systemic lupus erythematosus.
March 1990, Tissue antigens,
N K Mehra, and I Pande, and V Taneja, and S S Uppal, and S P Saxena, and A Kumar, and A N Malaviya
Association Between Major Histocompatibility Complex Class I Chain-Related Gene Polymorphisms and Susceptibility of Systemic Lupus Erythematosus.
October 2017, The American journal of the medical sciences,
N K Mehra, and I Pande, and V Taneja, and S S Uppal, and S P Saxena, and A Kumar, and A N Malaviya
Strong association between the major histocompatibility complex and systemic lupus erythematosus in southern Chinese.
December 1987, The Journal of rheumatology,
N K Mehra, and I Pande, and V Taneja, and S S Uppal, and S P Saxena, and A Kumar, and A N Malaviya
Associations between systemic lupus erythematosus and the major histocompatibility complex: clinical and immunological considerations.
August 1982, Clinical immunology and immunopathology,
N K Mehra, and I Pande, and V Taneja, and S S Uppal, and S P Saxena, and A Kumar, and A N Malaviya
Familial systemic lupus erythematosus: analysis of extended haplotypes of major histocompatibility complex antigens.
June 1995, Lupus,
Copied contents to your clipboard!