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Clinical studies on S-1108, a new oral cephem antibiotic, were carried out in the field of pediatrics. The following results were obtained. 1. The peak plasma level of S-1006 when administered after meal at a dose of 4 mg/kg was 2.47 micrograms/ml at an hour, and the serum half-life was 0.81 hour. The 4 hours urinary excretion rate of S-1006 was 35.7%. 2. S-1108 was administered to 15 children with various infections (3 patients with pneumonia, 3 with acute bronchitis, 4 with scarlet fever, 2 with acute tonsillitis, 1 with phlegmon and 2 with urinary tract infections). The overall clinical efficacy rate was 100%. 3. Side effects or abnormal laboratory test values were not observed except for diarrhea in 1 and eosinophilia in 1.
K Kuno, and
A Ogawa, and
F Hayakawa, and
K Ito, and
M Kondo, and
A Okumura, and
J Natsume
December 1993,
The Japanese journal of antibiotics,
K Kuno, and
A Ogawa, and
F Hayakawa, and
K Ito, and
M Kondo, and
A Okumura, and
J Natsume
December 1993,
The Japanese journal of antibiotics,
K Kuno, and
A Ogawa, and
F Hayakawa, and
K Ito, and
M Kondo, and
A Okumura, and
J Natsume
November 1993,
The Japanese journal of antibiotics,
K Kuno, and
A Ogawa, and
F Hayakawa, and
K Ito, and
M Kondo, and
A Okumura, and
J Natsume
December 1993,
The Japanese journal of antibiotics,
K Kuno, and
A Ogawa, and
F Hayakawa, and
K Ito, and
M Kondo, and
A Okumura, and
J Natsume
July 1995,
The Japanese journal of antibiotics,
K Kuno, and
A Ogawa, and
F Hayakawa, and
K Ito, and
M Kondo, and
A Okumura, and
J Natsume
November 1993,
The Japanese journal of antibiotics,
K Kuno, and
A Ogawa, and
F Hayakawa, and
K Ito, and
M Kondo, and
A Okumura, and
J Natsume
November 1993,
The Japanese journal of antibiotics,
K Kuno, and
A Ogawa, and
F Hayakawa, and
K Ito, and
M Kondo, and
A Okumura, and
J Natsume
December 1993,
The Japanese journal of antibiotics,
K Kuno, and
A Ogawa, and
F Hayakawa, and
K Ito, and
M Kondo, and
A Okumura, and
J Natsume
November 1993,
The Japanese journal of antibiotics,
K Kuno, and
A Ogawa, and
F Hayakawa, and
K Ito, and
M Kondo, and
A Okumura, and
J Natsume
November 1993,
The Japanese journal of antibiotics,
