BIOMAT Database Logo BIOMAT Database Logo

Randomized trial comparing first-trimester transcervical chorionic villus sampling and second-trimester amniocentesis. 1993

P Ammälä, and V K Hiilesmaa, and S Liukkonen, and T Saisto, and K Teramo, and H von Koskull
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.

A total of 800 patients were randomized at the 9th to 11th week of pregnancy either for transcervical chorionic villus sampling (CVS) on the day of trial entry or for amniocentesis (AC) at the 16th week. The indication for fetal karyotyping was maternal age in 94 per cent of the cases; the mean maternal age was 39.2 years. An adequate sample was obtained in 98.3 per cent of the cases in the CVS group and in all cases in the AC group. Retesting was indicated in 3.3 per cent of the CVS cases. An abnormal karyotype was found in 6.1 per cent of the CV samples and in 4.5 per cent of the amniotic fluid samples. There was one false-positive chromosome result in both groups. Twelve (3.1 per cent) miscarriages occurred by the 22nd week of pregnancy in the CVS group in pregnancies intended to continue. No difference was seen between the groups for total fetal loss rates. The number of surviving infants in the CVS group was 92.2 per cent and in the AC group 91.7 per cent (rate difference 0.5 per cent (95 per cent confidence interval -3.3 to 4.3)). In our study, both the diagnostic accuracy and the risk of fetal loss were equal in the CVS and AC groups.

UI MeSH Term Description Entries
D007621 Karyotyping Mapping of the KARYOTYPE of a cell. Karyotype Analysis Methods,Analysis Method, Karyotype,Analysis Methods, Karyotype,Karyotype Analysis Method,Karyotypings,Method, Karyotype Analysis,Methods, Karyotype Analysis
D007752 Obstetric Labor, Premature Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime during the 29th through 38th week of PREGNANCY. TOCOLYSIS inhibits premature labor and can prevent the BIRTH of premature infants (INFANT, PREMATURE). Preterm Labor,Labor, Premature,Premature Labor,Premature Obstetric Labor,Labor, Premature Obstetric,Labor, Preterm
D009030 Mosaicism The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011256 Pregnancy Outcome Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; or SPONTANEOUS ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO. Outcome, Pregnancy,Outcomes, Pregnancy,Pregnancy Outcomes
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D002821 Chorioamnionitis INFLAMMATION of the placental membranes (CHORION; AMNION) and connected tissues such as fetal BLOOD VESSELS and UMBILICAL CORD. It is often associated with intrauterine ascending infections during PREGNANCY. Amnionitis,Funisitis,Amnionitides,Chorioamnionitides,Funisitides
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D005189 False Positive Reactions Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed) False Positive Reaction,Positive Reaction, False,Positive Reactions, False,Reaction, False Positive,Reactions, False Positive
D005260 Female Females

Related Publications

P Ammälä, and V K Hiilesmaa, and S Liukkonen, and T Saisto, and K Teramo, and H von Koskull
First-trimester transcervical chorionic villus sampling by biopsy forceps versus mid-trimester amniocentesis: a randomized controlled trial project.
December 1999, Prenatal diagnosis,
P Ammälä, and V K Hiilesmaa, and S Liukkonen, and T Saisto, and K Teramo, and H von Koskull
Sampling success and risk by transabdominal chorionic villus sampling, transcervical chorionic villus sampling and amniocentesis: a randomized study.
March 1991, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology,
P Ammälä, and V K Hiilesmaa, and S Liukkonen, and T Saisto, and K Teramo, and H von Koskull
Comparison of first-trimester transvaginal amniocentesis with chorionic villus sampling and mid-trimester amniocentesis.
April 1994, Prenatal diagnosis,
P Ammälä, and V K Hiilesmaa, and S Liukkonen, and T Saisto, and K Teramo, and H von Koskull
Transabdominal versus transcervical chorionic villus sampling: a randomized trial.
August 1988, Human reproduction (Oxford, England),
P Ammälä, and V K Hiilesmaa, and S Liukkonen, and T Saisto, and K Teramo, and H von Koskull
Outcome after second-trimester amniocentesis and first-trimester chorionic villus sampling for prenatal diagnosis in multiple gestations.
April 2014, Ultraschall in der Medizin (Stuttgart, Germany : 1980),
P Ammälä, and V K Hiilesmaa, and S Liukkonen, and T Saisto, and K Teramo, and H von Koskull
Prenatal diagnosis in twin gestations: a comparison between second-trimester amniocentesis and first-trimester chorionic villus sampling.
July 1993, Obstetrics and gynecology,
P Ammälä, and V K Hiilesmaa, and S Liukkonen, and T Saisto, and K Teramo, and H von Koskull
Comparison of amniocentesis and transabdominal and transcervical chorionic villus sampling.
January 1993, Lancet (London, England),
P Ammälä, and V K Hiilesmaa, and S Liukkonen, and T Saisto, and K Teramo, and H von Koskull
Chorionic villus sampling in first trimester and fetoscopy in second trimester.
January 1987, Current problems in dermatology,
P Ammälä, and V K Hiilesmaa, and S Liukkonen, and T Saisto, and K Teramo, and H von Koskull
[Cytogenic accuracy of chorionic villus sampling and second trimester amniocentesis: is early amniocentesis an alternative?].
July 1991, Harefuah,
P Ammälä, and V K Hiilesmaa, and S Liukkonen, and T Saisto, and K Teramo, and H von Koskull
Transcervical chorionic villus sampling.
February 1987, American journal of obstetrics and gynecology,
Copied contents to your clipboard!