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In this study, 6 anesthetized dogs underwent global cardiac arrest for 1 hour, followed by reperfusion on bypass for 45 minutes. The hearts were then weaned off cardiopulmonary bypass and monitored for an additional 2 hours. Using modified Boyden chambers, high levels of neutrophil chemotactic activity were detected (using a checkerboard analysis) in the coronary sinus effluents obtained during cardiac arrest. The activity tended to decline during reperfusion. Assay of myeloperoxidase (a marker for neutrophils) revealed an accumulation of large numbers of neutrophils in the right (14 +/- 1.1 x 10(4) cells/g wet weight) and left (16 +/- 1 x 10(4) cells/g wet weight) ventricles after 2 hours of reperfusion. Light microscopy evaluation confirmed the presence of neutrophils, not only in the ventricles, but also in a greater number in the right and left atria. Electron microscopy study of these hearts revealed the presence of mild reversible changes, indicating good preservation of the hearts during arrest. Results of this study provide evidence for an acute inflammatory reaction that takes place after cardiac operations and suggest a role for myocardial tissues in the initiation of such a response through their release of neutrophil chemotactic factors.
S A Elgebaly, and
S L Houser, and
A F el Kerm, and
K Doyle, and
C Gillies, and
K Dalecki
December 1992,
The Annals of thoracic surgery,
S A Elgebaly, and
S L Houser, and
A F el Kerm, and
K Doyle, and
C Gillies, and
K Dalecki
January 2006,
Anesteziologiia i reanimatologiia,
S A Elgebaly, and
S L Houser, and
A F el Kerm, and
K Doyle, and
C Gillies, and
K Dalecki
February 1998,
The Annals of thoracic surgery,
S A Elgebaly, and
S L Houser, and
A F el Kerm, and
K Doyle, and
C Gillies, and
K Dalecki
October 1965,
The Journal of thoracic and cardiovascular surgery,
S A Elgebaly, and
S L Houser, and
A F el Kerm, and
K Doyle, and
C Gillies, and
K Dalecki
January 1997,
The Annals of thoracic surgery,
S A Elgebaly, and
S L Houser, and
A F el Kerm, and
K Doyle, and
C Gillies, and
K Dalecki
March 1965,
The New England journal of medicine,
S A Elgebaly, and
S L Houser, and
A F el Kerm, and
K Doyle, and
C Gillies, and
K Dalecki
August 1999,
The Annals of thoracic surgery,
S A Elgebaly, and
S L Houser, and
A F el Kerm, and
K Doyle, and
C Gillies, and
K Dalecki
August 1995,
The Annals of thoracic surgery,
S A Elgebaly, and
S L Houser, and
A F el Kerm, and
K Doyle, and
C Gillies, and
K Dalecki
September 1967,
Progress in cardiovascular diseases,
S A Elgebaly, and
S L Houser, and
A F el Kerm, and
K Doyle, and
C Gillies, and
K Dalecki
August 1989,
The Annals of thoracic surgery,
