Fetal diagnosis of fatal congenital heart disease. 1993

L D Allan
Guy's Hospital, London, United Kingdom.

The identification of the structure of the fetal heart became possible in the early 1980s as the resolution of ultrasound equipment improved. At that time, use of fetal echocardiography was confined to mothers whose fetuses were at increased risk of developing congenital heart disease, although only 10% of congenital heart disease occurs in this group. In 1985 a French group suggested that obstetricians involved in routine scanning be taught a simplified form of heart scanning, which made it possible to screen the general pregnant population for major anomalies. This form of heart scanning involved the examination of one section of the heart, the four-chamber view, and this approach greatly increased the potential impact of fetal echocardiography. As a result of the success of this program in both the United Kingdom and France, a continually increasing proportion of major cardiac defects are detected prenatally. There is almost no form of structural heart disease seen in a four-chamber projection during a routine scan that will not result in the eventual death of the child or young adult. Surgery may delay or defer this event, depending on the anatomic anomaly, but in general the outlook for affected children and their chance of reaching healthy adult life is poor. Most parents who learn this before 20 weeks of pregnancy will elect to interrupt the pregnancy. As a result a decline in the number of postnatal cases of some defects, such as the hypoplastic left-heart syndrome, can be documented in postnatal life.

UI MeSH Term Description Entries
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D005315 Fetal Diseases Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES. Embryopathies,Disease, Fetal,Diseases, Fetal,Embryopathy,Fetal Disease
D006330 Heart Defects, Congenital Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life. Congenital Heart Disease,Heart Abnormalities,Abnormality, Heart,Congenital Heart Defect,Congenital Heart Defects,Defects, Congenital Heart,Heart Defect, Congenital,Heart, Malformation Of,Congenital Heart Diseases,Defect, Congenital Heart,Disease, Congenital Heart,Heart Abnormality,Heart Disease, Congenital,Malformation Of Heart,Malformation Of Hearts
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000025 Abortion, Eugenic Abortion performed because of possible fetal defects. Eugenic Abortion,Abortion, Selective,Selective Abortion,Abortions, Eugenic,Abortions, Selective,Eugenic Abortions,Selective Abortions
D016216 Ultrasonography, Prenatal The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease. Fetal Ultrasonography,Prenatal Diagnosis, Ultrasonic,Ultrasonography, Fetal,Diagnosis, Prenatal Ultrasonic,Diagnosis, Ultrasonic Prenatal,Prenatal Ultrasonic Diagnosis,Prenatal Ultrasonography,Ultrasonic Diagnosis, Prenatal,Ultrasonic Prenatal Diagnosis,Diagnoses, Prenatal Ultrasonic,Diagnoses, Ultrasonic Prenatal,Prenatal Diagnoses, Ultrasonic,Prenatal Ultrasonic Diagnoses,Ultrasonic Diagnoses, Prenatal,Ultrasonic Prenatal Diagnoses

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