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Mapping nucleotide sequences onto a "DNA walk" produces a novel representation of DNA that can then be studied quantitatively using techniques derived from fractal landscape analysis. We used this method to analyze 11 complete genomic and cDNA myosin heavy chain (MHC) sequences belonging to 8 different species. Our analysis suggests an increase in fractal complexity for MHC genes with evolution with vertebrate > invertebrate > yeast. The increase in complexity is measured by the presence of long-range power-law correlations, which are quantified by the scaling exponent alpha. We develop a simple iterative model, based on known properties of polymeric sequences, that generates long-range nucleotide correlations from an initially noncorrelated coding region. This new model-as well as the DNA walk analysis-both support the intron-late theory of gene evolution.
S V Buldyrev, and
A L Goldberger, and
S Havlin, and
C K Peng, and
H E Stanley, and
M H Stanley, and
M Simons
January 1996,
Annual review of cell and developmental biology,
S V Buldyrev, and
A L Goldberger, and
S Havlin, and
C K Peng, and
H E Stanley, and
M H Stanley, and
M Simons
January 1994,
Society of General Physiologists series,
S V Buldyrev, and
A L Goldberger, and
S Havlin, and
C K Peng, and
H E Stanley, and
M H Stanley, and
M Simons
May 1986,
The Journal of biological chemistry,
S V Buldyrev, and
A L Goldberger, and
S Havlin, and
C K Peng, and
H E Stanley, and
M H Stanley, and
M Simons
June 1986,
Medicine and science in sports and exercise,
S V Buldyrev, and
A L Goldberger, and
S Havlin, and
C K Peng, and
H E Stanley, and
M H Stanley, and
M Simons
June 1987,
Circulation research,
S V Buldyrev, and
A L Goldberger, and
S Havlin, and
C K Peng, and
H E Stanley, and
M H Stanley, and
M Simons
December 2007,
Physiological genomics,
S V Buldyrev, and
A L Goldberger, and
S Havlin, and
C K Peng, and
H E Stanley, and
M H Stanley, and
M Simons
January 2001,
Journal of muscle research and cell motility,
S V Buldyrev, and
A L Goldberger, and
S Havlin, and
C K Peng, and
H E Stanley, and
M H Stanley, and
M Simons
December 1988,
Gene,
S V Buldyrev, and
A L Goldberger, and
S Havlin, and
C K Peng, and
H E Stanley, and
M H Stanley, and
M Simons
February 1989,
Journal of molecular biology,
S V Buldyrev, and
A L Goldberger, and
S Havlin, and
C K Peng, and
H E Stanley, and
M H Stanley, and
M Simons
March 1989,
The EMBO journal,
