Biomaterial Database

[The action of sulfur-containing and methemoglobin-forming compounds in renal ischemia]. 1993

N D Vorob'eva, and G D Anikin

Rat experiments demonstrated that cystamine showed a dose-dependent effect in renal ischemia. Ischemia was induced by ligation of renal vessels and the ureter for 90 minutes. Unithiol given in a single dose before ischemia produced no protective effect. Preadministration of sodium nitrite in doses causing slight to moderate hemic hypoxia could not diminish reoxygenation ischemic lesions.

UI	MeSH Term	Description	Entries
D007511	Ischemia	A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.	Ischemias
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008706	Methemoglobin		Ferrihemoglobin
D003538	Cystamine	A radiation-protective agent that interferes with sulfhydryl enzymes. It may also protect against carbon tetrachloride liver damage.	Cystineamine,Decarboxycystine,Diaminodiethyldisulfide,2,2'-Dithiobisethanamine,Cystamine Calcium Salt,Cystamine Diacetate,Cystamine Dihydrobromide,Cystamine Dihydrochloride,Cystamine Hydrobromide,Cystamine Hydrochloride,Cystamine Sulfate,Cystamine Sulfate (1:1),Cysteinamine Disulfide,Cystinamin,2,2' Dithiobisethanamine,Calcium Salt, Cystamine,Diacetate, Cystamine,Dihydrobromide, Cystamine,Dihydrochloride, Cystamine,Disulfide, Cysteinamine,Hydrobromide, Cystamine,Hydrochloride, Cystamine,Sulfate, Cystamine
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004353	Drug Evaluation, Preclinical	Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.	Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000860	Hypoxia	Sub-optimal OXYGEN levels in the ambient air of living organisms.	Anoxia,Oxygen Deficiency,Anoxemia,Deficiency, Oxygen,Hypoxemia,Deficiencies, Oxygen,Oxygen Deficiencies
D012977	Sodium Nitrite	Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.	Nitrite, Sodium
D014494	Unithiol	A chelating agent used as an antidote to heavy metal poisoning.	2,3-Dimercapto-1-propanesulfonic Acid,2,3-Dimercaptopropane 1-Sodium Sulfonate,2,3-Dimercaptopropane-1-sulfonate Sodium,2,3-Dimercaptopropanesulfonic Acid,DMPS,DMPS-Heyl,Dimaval,Mercuval,Sodium 2,3-Dimercaptopropane Sulfonate,Sodium 2,3-Dithiopropanesulfate,Unitiol,1-Sodium Sulfonate, 2,3-Dimercaptopropane,2,3 Dimercapto 1 propanesulfonic Acid,2,3 Dimercaptopropane 1 Sodium Sulfonate,2,3 Dimercaptopropane 1 sulfonate Sodium,2,3 Dimercaptopropanesulfonic Acid,2,3-Dimercaptopropane Sulfonate, Sodium,2,3-Dithiopropanesulfate, Sodium,DMPS Heyl