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Previous studies have shown that streptozotocin (STZ) induced diabetes in rats is associated with a decrease in the spontaneous rate of isolated right atria. Present experiments were designed to determine whether this model of insulin-dependent diabetes mellitus alters the chronotropic actions of cesium (Cs+). Right atrial preparations were isolated from STZ-treated and diluent-treated control rats, and bathed in Krebs-Henseleit buffer at 37 degrees C; dose-dependent (0.2-10 mM) effects of Cs+ were examined by cumulative addition. Preparations isolated from diabetic rats had a slower beating rate before exposure to Cs+, and the negative chronotropic response to this cation was diminished in these tissues. In fact, at concentrations between 2 and 10 mM Cs+, spontaneous rate did not differ between the diabetic and control groups. These data suggest that the hyperpolarization-activated current, I(f), may play a role in the slower spontaneous pacemaker rate observed in right atria isolated from STZ-induced diabetic rats.
R H Kennedy, and
K K Hicks, and
J R Stimers, and
E Seifen
February 1984,
The Journal of pharmacology and experimental therapeutics,
R H Kennedy, and
K K Hicks, and
J R Stimers, and
E Seifen
March 1983,
The Journal of pharmacy and pharmacology,
R H Kennedy, and
K K Hicks, and
J R Stimers, and
E Seifen
March 1994,
European journal of anaesthesiology,
R H Kennedy, and
K K Hicks, and
J R Stimers, and
E Seifen
January 1986,
British journal of pharmacology,
R H Kennedy, and
K K Hicks, and
J R Stimers, and
E Seifen
August 2001,
Journal of autonomic pharmacology,
R H Kennedy, and
K K Hicks, and
J R Stimers, and
E Seifen
August 1984,
The Journal of pharmacology and experimental therapeutics,
R H Kennedy, and
K K Hicks, and
J R Stimers, and
E Seifen
July 2004,
Journal of cardiovascular pharmacology,
R H Kennedy, and
K K Hicks, and
J R Stimers, and
E Seifen
November 1992,
General pharmacology,
R H Kennedy, and
K K Hicks, and
J R Stimers, and
E Seifen
January 1988,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
R H Kennedy, and
K K Hicks, and
J R Stimers, and
E Seifen
July 1990,
Arzneimittel-Forschung,
