Biomaterial Database

Concentration of thyroglobulin, iodine contents of thyroglobulin and of iodoaminoacids in human neonates thyroid glands. 1977

N Etling

The iodine and protein concentrations, the iodoamino acids content of thyroglobulin (TG) were determined in 17 thyroid tissues from human neonates who died from 3 hours to 47 days after birth. Total iodine concentration of neonate tissues increased with life duration. TG concentration was related to the survival duration of the neonates. Increase of the iodine content was associated to the increase of the TG content: mean value was 0.16 mug 127I/100 mug TG in neonates who died within the first 20 hours after birth, 0.25 mug in neonates who survived 26 to 72 hours and 0.43 mug in neonates living more than 10 days. Expressed as iodine content to total iodine ratio, iodoamino acid percentages were not related to the tissue. When the iodoamino acids were expressed in residues per molecule of TG, iodtyrosines, thyroxine and triiodothyronine increased with duration of survival. These variations in iodine content and concentration of thyroglobulin could be related to acute hormonal changes in serum observed in early neonatal period.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007455	Iodine	A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.	Iodine-127,Iodine 127
D007470	Monoiodotyrosine	A product from the iodination of tyrosine. In the biosynthesis of thyroid hormones (THYROXINE and TRIIODOTHYRONINE), tyrosine is first iodized to monoiodotyrosine.	Iodotyrosine
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013048	Specimen Handling	Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.	Specimen Collection,Collection, Specimen,Collections, Specimen,Handling, Specimen,Handlings, Specimen,Specimen Collections,Specimen Handlings
D013954	Thyroglobulin
D013961	Thyroid Gland	A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.	Thyroid,Gland, Thyroid,Glands, Thyroid,Thyroid Glands,Thyroids
D014284	Triiodothyronine	A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.	Liothyronine,T3 Thyroid Hormone,3,3',5-Triiodothyronine,Cytomel,Liothyronine Sodium,Thyroid Hormone, T3