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We investigated some ultrastructural aspects of platelet activity in patients with classic migraine during an attack-free period. We focused on the production of malondialdehyde (MDA), the intracellular concentration of Ca++ and the membrane phospholipid structure using a DPH (1,6 diphenyl-1,3,5 hexatriene) fluorescent probe. Our study comprised 20 patients with classic migraine and 5 healthy controls, from whom 10 cc samples of blood were collected in test tubes containing sodium citrate (1/9 cc). We found no significant differences in MDA production between migraineurs and controls either before or after stimulation with thrombin. The same applies to the concentration of intracellular Ca++ (Ca++i). The membrane lipid composition assessed by DPH fluorescent probe was normal both in migraineurs and in controls. Our findings suggest no intrinsic activation of platelet aggregation.
G De Matteis, and
M G Tozzi-Ciancarelli, and
P Calisse, and
R Totaro, and
F D'Andrea, and
C Di Massimo, and
M Prencipe
October 1988,
Acta neurologica Scandinavica,
G De Matteis, and
M G Tozzi-Ciancarelli, and
P Calisse, and
R Totaro, and
F D'Andrea, and
C Di Massimo, and
M Prencipe
April 1983,
Thrombosis and haemostasis,
G De Matteis, and
M G Tozzi-Ciancarelli, and
P Calisse, and
R Totaro, and
F D'Andrea, and
C Di Massimo, and
M Prencipe
November 1996,
Australasian chiropractic & osteopathy : journal of the Chiropractic & Osteopathic College of Australasia,
G De Matteis, and
M G Tozzi-Ciancarelli, and
P Calisse, and
R Totaro, and
F D'Andrea, and
C Di Massimo, and
M Prencipe
May 1987,
Ceskoslovenska neurologie a neurochirurgie,
G De Matteis, and
M G Tozzi-Ciancarelli, and
P Calisse, and
R Totaro, and
F D'Andrea, and
C Di Massimo, and
M Prencipe
April 1993,
Cephalalgia : an international journal of headache,
G De Matteis, and
M G Tozzi-Ciancarelli, and
P Calisse, and
R Totaro, and
F D'Andrea, and
C Di Massimo, and
M Prencipe
July 1983,
Headache,
G De Matteis, and
M G Tozzi-Ciancarelli, and
P Calisse, and
R Totaro, and
F D'Andrea, and
C Di Massimo, and
M Prencipe
February 1990,
Headache,
G De Matteis, and
M G Tozzi-Ciancarelli, and
P Calisse, and
R Totaro, and
F D'Andrea, and
C Di Massimo, and
M Prencipe
March 1989,
Cephalalgia : an international journal of headache,
G De Matteis, and
M G Tozzi-Ciancarelli, and
P Calisse, and
R Totaro, and
F D'Andrea, and
C Di Massimo, and
M Prencipe
June 1983,
Annals of neurology,
G De Matteis, and
M G Tozzi-Ciancarelli, and
P Calisse, and
R Totaro, and
F D'Andrea, and
C Di Massimo, and
M Prencipe
November 1990,
Neurologia (Barcelona, Spain),
