BIOMAT Database Logo BIOMAT Database Logo

Inward barium current and excitation-contraction coupling in frog twitch muscle fibres. 1993

S Blaineau, and V Jacquemond, and B Allard, and J Amsellem, and M J Moutin, and O Rougier
Laboratoire de Physiologie des Eléments Excitables, UA CNRS 180, Université Claude Bernard, Villeurbanne, France.

The role of barium ions in excitation-contraction coupling was studied in single isolated frog semitendinosus fibres. Simultaneous recordings of membrane currents and contraction under voltage-clamp conditions in a sucrose-vaseline gap device show that barium ions have a reversible inhibiting effect on contraction. This inhibiting action was correlated to the entry of barium ions via the DHP-sensitive tubular calcium channel. Cytological observations and X-ray microanalysis performed on the fibres used in the electrophysiological experiments indicate that barium ions do not accumulate in the junctional sarcoplasmic reticulum; they can freely diffuse in the intermyofibrillar space and they accumulate in mitochondria. Calcium release experiments performed on isolated sarcoplasmic reticulum vesicles show that barium ions are not able to induce calcium release from calcium-loaded vesicles, they behave as calcium release inhibitors. These results are discussed in relation with the possible role of the slow Ca current in excitation-contraction coupling.

UI MeSH Term Description Entries
D008564 Membrane Potentials The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization). Resting Potentials,Transmembrane Potentials,Delta Psi,Resting Membrane Potential,Transmembrane Electrical Potential Difference,Transmembrane Potential Difference,Difference, Transmembrane Potential,Differences, Transmembrane Potential,Membrane Potential,Membrane Potential, Resting,Membrane Potentials, Resting,Potential Difference, Transmembrane,Potential Differences, Transmembrane,Potential, Membrane,Potential, Resting,Potential, Transmembrane,Potentials, Membrane,Potentials, Resting,Potentials, Transmembrane,Resting Membrane Potentials,Resting Potential,Transmembrane Potential,Transmembrane Potential Differences
D008931 Mitochondria, Muscle Mitochondria of skeletal and smooth muscle. It does not include myocardial mitochondria for which MITOCHONDRIA, HEART is available. Sarcosomes,Mitochondrion, Muscle,Muscle Mitochondria,Muscle Mitochondrion,Sarcosome
D009119 Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009132 Muscles Contractile tissue that produces movement in animals. Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D011898 Ranidae The family of true frogs of the order Anura. The family occurs worldwide except in Antarctica. Frogs, True,Rana,Frog, True,True Frog,True Frogs
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D004577 Electron Probe Microanalysis Identification and measurement of ELEMENTS and their location based on the fact that X-RAYS emitted by an element excited by an electron beam have a wavelength characteristic of that element and an intensity related to its concentration. It is performed with an electron microscope fitted with an x-ray spectrometer, in scanning or transmission mode. Microscopy, Electron, X-Ray Microanalysis,Spectrometry, X-Ray Emission, Electron Microscopic,Spectrometry, X-Ray Emission, Electron Probe,X-Ray Emission Spectrometry, Electron Microscopic,X-Ray Emission Spectrometry, Electron Probe,X-Ray Microanalysis, Electron Microscopic,X-Ray Microanalysis, Electron Probe,Microanalysis, Electron Probe,Spectrometry, X Ray Emission, Electron Microscopic,Spectrometry, X Ray Emission, Electron Probe,X Ray Emission Spectrometry, Electron Microscopic,X Ray Emission Spectrometry, Electron Probe,X-Ray Microanalysis,Electron Probe Microanalyses,Microanalyses, Electron Probe,Microanalysis, X-Ray,Probe Microanalyses, Electron,Probe Microanalysis, Electron,X Ray Microanalysis,X Ray Microanalysis, Electron Microscopic,X Ray Microanalysis, Electron Probe
D004594 Electrophysiology The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.

Related Publications

S Blaineau, and V Jacquemond, and B Allard, and J Amsellem, and M J Moutin, and O Rougier
Effect of barium ions on excitation-contraction coupling of frog twitch muscle fibres.
January 1990, The Japanese journal of physiology,
S Blaineau, and V Jacquemond, and B Allard, and J Amsellem, and M J Moutin, and O Rougier
Extracellular ions and excitation-contraction coupling in frog twitch muscle fibres.
June 1984, The Journal of physiology,
S Blaineau, and V Jacquemond, and B Allard, and J Amsellem, and M J Moutin, and O Rougier
Transition temperature of excitation-contraction coupling in frog twitch muscle fibres.
July 1979, Nature,
S Blaineau, and V Jacquemond, and B Allard, and J Amsellem, and M J Moutin, and O Rougier
Slow inward barium current and contraction on frog single muscle fibres.
June 1980, The Journal of physiology,
S Blaineau, and V Jacquemond, and B Allard, and J Amsellem, and M J Moutin, and O Rougier
Barium ions and excitation-contraction coupling of frog single muscle fibres under controlled current and voltage.
October 1977, Journal de physiologie,
S Blaineau, and V Jacquemond, and B Allard, and J Amsellem, and M J Moutin, and O Rougier
Inward calcium current in twitch muscle fibres of the frog.
October 1978, The Journal of physiology,
S Blaineau, and V Jacquemond, and B Allard, and J Amsellem, and M J Moutin, and O Rougier
Inward calcium current in twitch muscle fibres of the frog [proceedings].
September 1976, The Journal of physiology,
S Blaineau, and V Jacquemond, and B Allard, and J Amsellem, and M J Moutin, and O Rougier
Effect of activation of protein kinase C on excitation-contraction coupling in frog twitch muscle fibres.
October 1994, Pflugers Archiv : European journal of physiology,
S Blaineau, and V Jacquemond, and B Allard, and J Amsellem, and M J Moutin, and O Rougier
Effects of 2,3-butanedione monoxime on excitation-contraction coupling in frog twitch fibres.
November 1998, Journal of muscle research and cell motility,
S Blaineau, and V Jacquemond, and B Allard, and J Amsellem, and M J Moutin, and O Rougier
Valinomycin and excitation-contraction coupling in skeletal muscle fibres of the frog.
April 1992, The Journal of physiology,
Copied contents to your clipboard!