Biomaterial Database

[Epidural buprenorphine under nitrous oxide-oxygen-enflurane anesthesia in elderly patients]. 1993

C Tachibana, and K Satoh, and Y Ohe, and N Hashimoto, and Y Furuya

Department of Anesthesiology, Tokyo Women's Medical College Daini Hospital.

The effects of epidural buprenorphine (Bn) under nitrous oxide-oxygen-enflurane (E) anesthesia in elderly patients were examined. The subjects were older than 65 years (n = 82) and scheduled for abdominal surgery. They were divided randomly into two groups according to epidural drugs used. The first group received epidural Bn 0.1-0.2 mg (group B, n = 41). The second group received epidural Bn 0.1-0.2mg + 1% lidocaine (group BL, n = 41). The enflurane concentration was 1.13% in group B, and it was significantly higher than 0.78% of group BL (P < 0.01). There was no intra-group difference in the highest systolic blood pressure during operation. The lowest systolic blood pressure during operation was 92.0 +/- 2.1 mmHg in group BL and it was significantly lower than 100.2 +/- 2.9 mmHg of group B (P < 0.05). The percentage of patients who needed vasoconstrictor drugs was 12% in group B, and it was significantly smaller than 42% of group BL (P < 0.01). On the other hand the percentage of patients who needed vasodilator drugs was 39% in group B, and it was significantly larger than 17% of group BL (P < 0.05). There was no intra-group difference in arousing time from anesthesia. Concerning the postoperative respiratory state, there was no intra-group difference in the respiratory rate, tidal volume and PaO2. But the PaCO2 value was 44.7 +/- 0.8 (mean +/- SE) mmHg in group BL, and it was significantly higher than 40.7 +/- 0.7 mmHg of group B (P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D007432	Intraoperative Period	The period during a surgical operation.	Intraoperative Periods,Period, Intraoperative,Periods, Intraoperative
D008297	Male		Males
D009609	Nitrous Oxide	Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.	Laughing Gas,Nitrogen Protoxide,Gas, Laughing,Oxide, Nitrous
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002047	Buprenorphine	A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.	6029-M,Buprenex,Buprenorphine Hydrochloride,Buprex,Prefin,RX-6029-M,Subutex,Temgesic,Temgésic,6029 M,6029M,Hydrochloride, Buprenorphine,RX 6029 M,RX6029M
D004737	Enflurane	An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.	Alyrane,Enfran,Enlirane,Ethrane,Etran
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man