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[Basic and clinical studies of serum CA195 antigen assay with "BL-CA195" kit]. 1993
M Kobayashi, and
A Yamaguchi, and
T Imai, and
H Otake, and
H Igarashi, and
N Hatori, and
K Tomiyoshi, and
T Inoue, and
K Endo, and
H Sakahara
Department of Nuclear Medicine, Gunma University School of Medicine, Maebashi.
We performed basic and clinical studies of IRMA "BL-CA195" kit in which monoclonal antibody CC3C195 was used as 125I-labeled tracer and solid phase antibody. The reproducibility of the assay results and dilution curves were satisfactory. There was a close correlation between serum CA195 and CA19-9 values, and many patients with pancreatic and colorectal cancer had elevated serum CA195 concentrations. Unlabeled CC3C195 antibody dose-dependently and completely inhibited the binding of 125I-labeled anti-CA19-9 antibody to its corresponding antigen. These findings suggest that CA195 and CA19-9 share common antigenic determinants.
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