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In a prospectively randomized study 60 hips at high risk for heterotopic ossification (HO) received prophylactic radiotherapy (RT). Randomization was performed between a low dose (LD-RT) of 5 x 2 Gy (arm A: 32 patients) and a high dose (HD-RT) of either 10 x 2 Gy (arm B1; 8 patients) or 5 x 3.5 Gy (arm B2; 20 patients). Relevant patient and risk factors were equally distributed in both treatment arms. 4 (7%) patients developed treatment failures. A short delay of RT after postoperative day (POD) 4 was significantly correlated with failure (p < 0.001). The results suggest no difference in prophylactic efficacy between LD-RT and HD-RT treatment. 2/19 (11%) patients receiving additional diphosphonates and 2/18 (11%) on no medication failed RT treatment, but none on indomethacin did so. In conclusion, immediate postoperative RT has been shown to be an effective prophylactic treatment.
M H Seegenschmiedt, and
A R Goldmann, and
R Wölfel, and
D Hohmann, and
H Beck, and
R Sauer
February 1994,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
M H Seegenschmiedt, and
A R Goldmann, and
R Wölfel, and
D Hohmann, and
H Beck, and
R Sauer
January 1994,
Journal of back and musculoskeletal rehabilitation,
M H Seegenschmiedt, and
A R Goldmann, and
R Wölfel, and
D Hohmann, and
H Beck, and
R Sauer
July 1990,
Orthopaedic review,
M H Seegenschmiedt, and
A R Goldmann, and
R Wölfel, and
D Hohmann, and
H Beck, and
R Sauer
August 2003,
Pharmacy world & science : PWS,
M H Seegenschmiedt, and
A R Goldmann, and
R Wölfel, and
D Hohmann, and
H Beck, and
R Sauer
January 1997,
Chirurgia narzadow ruchu i ortopedia polska,
M H Seegenschmiedt, and
A R Goldmann, and
R Wölfel, and
D Hohmann, and
H Beck, and
R Sauer
December 1999,
Clinical orthopaedics and related research,
M H Seegenschmiedt, and
A R Goldmann, and
R Wölfel, and
D Hohmann, and
H Beck, and
R Sauer
August 2008,
International journal of radiation oncology, biology, physics,
M H Seegenschmiedt, and
A R Goldmann, and
R Wölfel, and
D Hohmann, and
H Beck, and
R Sauer
September 2004,
Revue medicale de la Suisse romande,
M H Seegenschmiedt, and
A R Goldmann, and
R Wölfel, and
D Hohmann, and
H Beck, and
R Sauer
January 2007,
Ortopedia, traumatologia, rehabilitacja,
M H Seegenschmiedt, and
A R Goldmann, and
R Wölfel, and
D Hohmann, and
H Beck, and
R Sauer
December 1986,
The Journal of bone and joint surgery. American volume,
