[The risk factors for breast cancer: a case-control study]. 1993

L Gandra, and H Barros, and A Moreira, and F Calheiros, and N Magalhães
Departamento de Cirurgia do Centro Hospitalar de Gaia (Unidades B e C), Porto.

In western countries, female breast cancer is a major cause of death. Many risk factors for breast cancer have been identified, but the magnitude of the risks is clearly different between high and low risk areas. In this hospital-based case-control study we evaluated risk factors for female breast cancer in 158 women with breast cancer and 131 controls. Cases presented a later age at first birth and a lower median number of pregnancies. The risk of breast cancer increased with increasing age at first birth, particularly for women with lower parity. After controlling for other variables the risk significantly decreased with abortion history (OR = 0.5, 95% CI: 0.3-0.7) and oral contraception (OR = 0.5, 95% CI: 0.3-0.9). Premenopausal and postmenopausal women presented different risk factors. Among premenopausal cases the risk was lower for parous women (OR = 0.1, 95% CI: 0.0-0.7) and higher for those with a positive family history (OR = 4.5, 95% CI: 1.3-16). Compared to controls, postmenopausal cases only presented a significantly lower rate of abortions (OR = 0.2, 95% CI: 0.1-0.4). The present study shows that these women can be regarded as belonging to an intermediate risk population.

UI MeSH Term Description Entries
D008593 Menopause The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age. Change of Life, Female
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011174 Portugal A country in southwestern Europe, bordering the North Atlantic Ocean, west of Spain. The capital is Lisbon. Madeira Island,Portuguese Republic
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D015995 Prevalence The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time. Period Prevalence,Point Prevalence,Period Prevalences,Point Prevalences,Prevalence, Period,Prevalence, Point,Prevalences
D016001 Confidence Intervals A range of values for a variable of interest, e.g., a rate, constructed so that this range has a specified probability of including the true value of the variable. Confidence Interval,Interval, Confidence,Intervals, Confidence

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