BIOMAT Database Logo BIOMAT Database Logo

Genetic events in sporadic colorectal adenomas: K-ras and p53 heterozygous mutations are not sufficient for malignant progression. 1993

L De Benedetti, and L Varesco, and N S Pellegata, and L Losi, and V Gismondi, and L Casarino, and S Sciallero, and L Bonelli, and R Biticchi, and A Bafico
IST, National Cancer Institute, Genova, Italy.

Twenty-four sporadic colorectal adenomas were analysed for the presence of allelic loss on the short arm of chromosome 17 as well as mutations in the K-ras and p53 genes. Chromosome 17p13 allelic loss was not present in 14 out of 14 informative cases. K-ras mutations were observed in 15 out of 24 cases. A p53 gene mutation (GGC-->GAC at codon 245) was detected in two biopsies taken at a four year interval from a recurrent rectal villous adenoma. Both biopsies also contained the same K-ras gene mutation (GGT-->GTT at codon 12). The data from the recurrent rectal adenoma provide in vivo evidence that K-ras and p53 heterozygous mutations confer a proliferative advantage but together are not sufficient for malignant transformation.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011905 Genes, ras Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein. Ha-ras Genes,Ki-ras Genes,N-ras Genes,c-Ha-ras Genes,c-Ki-ras Genes,c-N-ras Genes,ras Genes,v-Ha-ras Genes,v-Ki-ras Genes,H-ras Genes,H-ras Oncogenes,Ha-ras Oncogenes,K-ras Genes,K-ras Oncogenes,Ki-ras Oncogenes,N-ras Oncogenes,c-H-ras Genes,c-H-ras Proto-Oncogenes,c-Ha-ras Proto-Oncogenes,c-K-ras Genes,c-K-ras Proto-Oncogenes,c-Ki-ras Proto-Oncogenes,c-N-ras Proto-Oncogenes,ras Oncogene,v-H-ras Genes,v-H-ras Oncogenes,v-Ha-ras Oncogenes,v-K-ras Genes,v-K-ras Oncogenes,v-Ki-ras Oncogenes,Gene, Ha-ras,Gene, Ki-ras,Gene, v-Ha-ras,Gene, v-Ki-ras,Genes, Ha-ras,Genes, Ki-ras,Genes, N-ras,Genes, v-Ha-ras,Genes, v-Ki-ras,H ras Genes,H ras Oncogenes,H-ras Gene,H-ras Oncogene,Ha ras Genes,Ha ras Oncogenes,Ha-ras Gene,Ha-ras Oncogene,K ras Genes,K ras Oncogenes,K-ras Gene,K-ras Oncogene,Ki ras Genes,Ki ras Oncogenes,Ki-ras Gene,Ki-ras Oncogene,N ras Genes,N ras Oncogenes,N-ras Gene,N-ras Oncogene,c H ras Genes,c H ras Proto Oncogenes,c Ha ras Genes,c Ha ras Proto Oncogenes,c K ras Genes,c K ras Proto Oncogenes,c Ki ras Genes,c Ki ras Proto Oncogenes,c N ras Genes,c N ras Proto Oncogenes,c-H-ras Gene,c-H-ras Proto-Oncogene,c-Ha-ras Gene,c-Ha-ras Proto-Oncogene,c-K-ras Gene,c-K-ras Proto-Oncogene,c-Ki-ras Gene,c-Ki-ras Proto-Oncogene,c-N-ras Gene,c-N-ras Proto-Oncogene,ras Gene,ras Oncogenes,v H ras Genes,v H ras Oncogenes,v Ha ras Genes,v Ha ras Oncogenes,v K ras Genes,v K ras Oncogenes,v Ki ras Genes,v Ki ras Oncogenes,v-H-ras Gene,v-H-ras Oncogene,v-Ha-ras Gene,v-Ha-ras Oncogene,v-K-ras Gene,v-K-ras Oncogene,v-Ki-ras Gene,v-Ki-ras Oncogene
D002872 Chromosome Deletion Actual loss of portion of a chromosome. Monosomy, Partial,Partial Monosomy,Deletion, Chromosome,Deletions, Chromosome,Monosomies, Partial,Partial Monosomies
D002886 Chromosomes, Human, Pair 17 A specific pair of GROUP E CHROMOSOMES of the human chromosome classification. Chromosome 17
D003062 Codon A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, but some organisms do not produce the transfer RNAs (RNA, TRANSFER) complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE). Codon, Sense,Sense Codon,Codons,Codons, Sense,Sense Codons
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000236 Adenoma A benign epithelial tumor with a glandular organization. Adenoma, Basal Cell,Adenoma, Follicular,Adenoma, Microcystic,Adenoma, Monomorphic,Adenoma, Papillary,Adenoma, Trabecular,Adenomas,Adenomas, Basal Cell,Adenomas, Follicular,Adenomas, Microcystic,Adenomas, Monomorphic,Adenomas, Papillary,Adenomas, Trabecular,Basal Cell Adenoma,Basal Cell Adenomas,Follicular Adenoma,Follicular Adenomas,Microcystic Adenoma,Microcystic Adenomas,Monomorphic Adenoma,Monomorphic Adenomas,Papillary Adenoma,Papillary Adenomas,Trabecular Adenoma,Trabecular Adenomas
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

L De Benedetti, and L Varesco, and N S Pellegata, and L Losi, and V Gismondi, and L Casarino, and S Sciallero, and L Bonelli, and R Biticchi, and A Bafico
K-ras mutations in incident sporadic colorectal adenomas.
March 2006, Cancer,
L De Benedetti, and L Varesco, and N S Pellegata, and L Losi, and V Gismondi, and L Casarino, and S Sciallero, and L Bonelli, and R Biticchi, and A Bafico
High frequency of K-ras mutations in sporadic colorectal adenomas.
March 1993, Gut,
L De Benedetti, and L Varesco, and N S Pellegata, and L Losi, and V Gismondi, and L Casarino, and S Sciallero, and L Bonelli, and R Biticchi, and A Bafico
p53 expression and K-ras mutation in colorectal adenomas.
May 1993, Gut,
L De Benedetti, and L Varesco, and N S Pellegata, and L Losi, and V Gismondi, and L Casarino, and S Sciallero, and L Bonelli, and R Biticchi, and A Bafico
No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.
November 2000, Digestive diseases and sciences,
L De Benedetti, and L Varesco, and N S Pellegata, and L Losi, and V Gismondi, and L Casarino, and S Sciallero, and L Bonelli, and R Biticchi, and A Bafico
Intratumor heterogeneity of k-ras and p53 mutations among human colorectal adenomas containing early cancer.
January 2000, Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology,
L De Benedetti, and L Varesco, and N S Pellegata, and L Losi, and V Gismondi, and L Casarino, and S Sciallero, and L Bonelli, and R Biticchi, and A Bafico
APC mutations are sufficient for the growth of early colorectal adenomas.
February 2000, Proceedings of the National Academy of Sciences of the United States of America,
L De Benedetti, and L Varesco, and N S Pellegata, and L Losi, and V Gismondi, and L Casarino, and S Sciallero, and L Bonelli, and R Biticchi, and A Bafico
Simultaneous mutations in K-ras and TP53 are indicative of poor prognosis in sporadic colorectal cancer.
February 2004, American journal of clinical oncology,
L De Benedetti, and L Varesco, and N S Pellegata, and L Losi, and V Gismondi, and L Casarino, and S Sciallero, and L Bonelli, and R Biticchi, and A Bafico
K-ras and p53 mutations in human colorectal aberrant crypt foci.
March 1996, The Journal of pathology,
L De Benedetti, and L Varesco, and N S Pellegata, and L Losi, and V Gismondi, and L Casarino, and S Sciallero, and L Bonelli, and R Biticchi, and A Bafico
K-ras and p53 mutations in hereditary non-polyposis colorectal cancers.
February 1997, International journal of cancer,
L De Benedetti, and L Varesco, and N S Pellegata, and L Losi, and V Gismondi, and L Casarino, and S Sciallero, and L Bonelli, and R Biticchi, and A Bafico
Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas.
July 1993, Journal of the National Cancer Institute,
Copied contents to your clipboard!