BIOMAT Database Logo BIOMAT Database Logo

Extravascular lung water measured with 99mTc-RBC and 99mTc-DTPA is increased in left-sided heart failure. 1993

M Nawada, and K Gotoh, and Y Yagi, and S Ohshima, and N Yamamoto, and F Deguchi, and T Sawa, and H Tanaka, and M Yamaguchi, and H Uemura
Second Department of Internal Medicine, Gifu University School of Medicine, Japan.

Extravascular lung water (EVLW) was quantitatively measured in 81 patients consisting of 10 subjects with normal cardiac function and 71 patients with left-sided heart diseases, using 99mTc-RBC as a non-diffusible indicator and 99mTc-DTPA as a diffusible indicator in the equilibrium phase. EVLW averaged 3.0 +/- 1.4 (ml/kg, mean +/- SD) in subjects with normal cardiac function (n = 10), 4.3 +/- 1.7 in New York Heart Association functional class I patients (n = 30), 4.8 +/- 2.4 in NYHA functional class II patients (n = 33) and 9.4 +/- 5.4 in NYHA functional class III (n = 8) patients. EVLW was greater in NYHA class III than in normal controls or NYHA classes I or II (p < 0.01). Lung thermal volume (LTV) was also measured in 31 of the 81 patients using a double indicator dilution technique with sodium and heat. LTV averaged 6.0 +/- 1.2 (ml/kg) in normal subjects (n = 4), 8.6 +/- 2.0 in NYHA functional class I patients (n = 11), 9.7 +/- 3.0 in NYHA functional class II patients (n = 13), and 15.9 +/- 8.2 in NYHA functional class III patients (n = 3). The correlation between EVLW and LTV was significant (EVLW = 0.79 x LTV - 72.8, r = 0.80, p < 0.01). There were significant differences in EVLW/LTV ratio between NYHA class III (0.93 +/- 0.16) and NYHA class I (0.62 +/- 0.22). Thus, it was shown that EVLW was increased in left-sided heart failure and that LTV overestimated the EVLW.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D002303 Cardiac Output, Low A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities. Low Cardiac Output,Low Cardiac Output Syndrome,Output, Low Cardiac
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D013667 Technetium The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, and atomic number 43. All technetium isotopes are radioactive. Technetium 99m (m Technetium 99m,99m, Technetium
D015633 Extravascular Lung Water Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space. Lung Water, Extravascular,Extra Vascular Lung Water,Lung Water, Extra Vascular,Water, Extravascular Lung

Related Publications

M Nawada, and K Gotoh, and Y Yagi, and S Ohshima, and N Yamamoto, and F Deguchi, and T Sawa, and H Tanaka, and M Yamaguchi, and H Uemura
[Determination of regional extravascular lung water in heart failure].
February 1984, Zeitschrift fur Kardiologie,
M Nawada, and K Gotoh, and Y Yagi, and S Ohshima, and N Yamamoto, and F Deguchi, and T Sawa, and H Tanaka, and M Yamaguchi, and H Uemura
[Left sided heart failure and right sided heart failure].
April 2007, Nihon rinsho. Japanese journal of clinical medicine,
M Nawada, and K Gotoh, and Y Yagi, and S Ohshima, and N Yamamoto, and F Deguchi, and T Sawa, and H Tanaka, and M Yamaguchi, and H Uemura
[Radionuclide cardioangiography using 99mTc-DTPA-HSA in comparison with in vivo 99mTc-RBC labeling].
May 1988, Kaku igaku. The Japanese journal of nuclear medicine,
M Nawada, and K Gotoh, and Y Yagi, and S Ohshima, and N Yamamoto, and F Deguchi, and T Sawa, and H Tanaka, and M Yamaguchi, and H Uemura
[Acute left-sided heart failure].
December 2009, MMW Fortschritte der Medizin,
M Nawada, and K Gotoh, and Y Yagi, and S Ohshima, and N Yamamoto, and F Deguchi, and T Sawa, and H Tanaka, and M Yamaguchi, and H Uemura
Effect of prostaglandin E1 on extravascular lung water in patients with severe heart failure.
January 1997, American journal of therapeutics,
M Nawada, and K Gotoh, and Y Yagi, and S Ohshima, and N Yamamoto, and F Deguchi, and T Sawa, and H Tanaka, and M Yamaguchi, and H Uemura
[Effect of prostaglandin E1 on extravascular lung water in patients with severe heart failure].
January 1996, Wiener klinische Wochenschrift,
M Nawada, and K Gotoh, and Y Yagi, and S Ohshima, and N Yamamoto, and F Deguchi, and T Sawa, and H Tanaka, and M Yamaguchi, and H Uemura
Pulmonary hypertension associated with left-sided heart failure.
November 2020, Current opinion in cardiology,
M Nawada, and K Gotoh, and Y Yagi, and S Ohshima, and N Yamamoto, and F Deguchi, and T Sawa, and H Tanaka, and M Yamaguchi, and H Uemura
Background in the 99mTc DTPA renogram: analysis of intravascular and extravascular components.
January 1987, American journal of physiologic imaging,
M Nawada, and K Gotoh, and Y Yagi, and S Ohshima, and N Yamamoto, and F Deguchi, and T Sawa, and H Tanaka, and M Yamaguchi, and H Uemura
Morphologic and physiologic correlates of increased extravascular lung water.
August 1984, Surgery,
M Nawada, and K Gotoh, and Y Yagi, and S Ohshima, and N Yamamoto, and F Deguchi, and T Sawa, and H Tanaka, and M Yamaguchi, and H Uemura
Aerosolized gadolinium-DTPA enhances the magnetic resonance signal of extravascular lung water.
May 1987, Investigative radiology,
Copied contents to your clipboard!