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Thirty-four primary, untreated sporadic breast cancers were examined for loss of heterozygosity (LOH) at tumour suppressor loci involved in colorectal cancer: APC/MCC at 5q21 and DCC at 18q21. LOH was identified in 28% informative patients at 5q21 and 31% at 18q21. LOH at 5q21 and 18q21 was compared with allele loss at 17p13 and concurrent LOH at two or more of the loci was noted in 24% of tumours. Expression of a 12 kb DCC mRNA was demonstrated in 14/34 (42%) of the cancers and in all five tumours with LOH at the DCC locus there was an additional 11 kb DCC mRNA. Abnormalities of three loci involved in colorectal cancer (5q21, 17p13 and 18q21) therefore also occur in sporadic breast cancer. The accumulation of such genetic abnormalities may confer a growth advantage important in the development of breast cancer.
A M Thompson, and
R G Morris, and
M Wallace, and
A H Wyllie, and
C M Steel, and
D C Carter
June 1999,
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih,
A M Thompson, and
R G Morris, and
M Wallace, and
A H Wyllie, and
C M Steel, and
D C Carter
July 1999,
Journal of clinical pathology,
A M Thompson, and
R G Morris, and
M Wallace, and
A H Wyllie, and
C M Steel, and
D C Carter
October 2000,
Biochimica et biophysica acta,
A M Thompson, and
R G Morris, and
M Wallace, and
A H Wyllie, and
C M Steel, and
D C Carter
November 1994,
British journal of cancer,
A M Thompson, and
R G Morris, and
M Wallace, and
A H Wyllie, and
C M Steel, and
D C Carter
December 1996,
Pathology, research and practice,
A M Thompson, and
R G Morris, and
M Wallace, and
A H Wyllie, and
C M Steel, and
D C Carter
September 1999,
Histopathology,
A M Thompson, and
R G Morris, and
M Wallace, and
A H Wyllie, and
C M Steel, and
D C Carter
January 1999,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
A M Thompson, and
R G Morris, and
M Wallace, and
A H Wyllie, and
C M Steel, and
D C Carter
January 1990,
British journal of cancer,
A M Thompson, and
R G Morris, and
M Wallace, and
A H Wyllie, and
C M Steel, and
D C Carter
July 1996,
Zhonghua nei ke za zhi,
A M Thompson, and
R G Morris, and
M Wallace, and
A H Wyllie, and
C M Steel, and
D C Carter
January 1999,
Pathology, research and practice,
