Biomaterial Database

Selective growth inhibition of the male progeny of mice treated with trimethylamine during pregnancy. 1993

I Guest, and D R Varma

Department of Pharmacology and Therapeutics, McGill University, Montréal, Que., Canada.

Injections of 1-7.5 mmol trimethylamine (TMA) per kilogram into mice daily from day 6 to day 15 (period of organogenesis) of gestation caused a dose-dependent decrease in fetal weights and in postnatal growth. The decrease in postnatal body weight gain, in brain and kidney weights, and in brain protein and DNA was more marked in the male than in the female offspring of TMA-treated animals; seminal vesicle weight and serum testosterone levels were also reduced. It is suggested that the selective growth inhibition of male progeny might be due to a decrease in testosterone synthesis. Since endogenous TMA levels are influenced by renal and liver disease and food habits, it might be one of the environmental factors influencing pregnancy outcome.

UI	MeSH Term	Description	Entries
D008098	Litter Size	The number of offspring produced at one birth by a viviparous animal.	Litter Sizes,Size, Litter,Sizes, Litter
D008297	Male		Males
D008744	Methylamines	Derivatives of methylamine (the structural formula CH3NH2).
D009419	Nerve Tissue Proteins		Proteins, Nerve Tissue,Tissue Proteins, Nerve
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011248	Pregnancy Complications	Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.	Adverse Birth Outcomes,Complications, Pregnancy,Adverse Birth Outcome,Birth Outcome, Adverse,Complication, Pregnancy,Outcome, Adverse Birth,Pregnancy Complication
D011297	Prenatal Exposure Delayed Effects	The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.	Delayed Effects, Prenatal Exposure,Late Effects, Prenatal Exposure
D001724	Birth Weight	The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.	Birthweight,Birth Weights,Birthweights,Weight, Birth,Weights, Birth
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon