Biomaterial Database

Cellular inflammatory responses to direct restorative composite resins. 1993

C Hansasuta, and M E Neiders, and A Aguirre, and R E Cohen

Department of Periodontology, State University of New York, School of Dental Medicine, Buffalo.

As a result of shaping, finishing, or removal of dental composite resin restorations, resin particles may become trapped and embedded in oral tissues. However, tissue reactions induced by entrapped composite resin particles have not been thoroughly examined. To assess the soft tissue inflammatory response to composite restorative materials, three commercial dental composite resin suspensions were implanted subcutaneously in rats. Implantation resulted in a granulomatous inflammatory reaction that persisted 8 weeks after placement. The lesion was characterized by an influx of lymphocytes and the presence of fibroblasts and epithelioid cells. Composite resin particles have the potential to cause persistent inflammation if they are entrapped in oral tissues.

UI	MeSH Term	Description	Entries
D011109	Polymethacrylic Acids	Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer.	Methacrylic Acid Polymers,Acid Polymers, Methacrylic,Acids, Polymethacrylic,Polymers, Methacrylic Acid
D011140	Polyurethanes	A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.	Polyisocyanates,Ostamer,Pellethane,Spandex,Ostamers,Pellethanes,Polyisocyanate,Polyurethane,Spandices
D003188	Composite Resins	Synthetic resins, containing an inert filler, that are widely used in dentistry.	Composite Resin,Resin, Composite,Resins, Composite
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015745	Granuloma, Foreign-Body	Histiocytic, inflammatory response to a foreign body. It consists of modified macrophages with multinucleated giant cells, in this case foreign-body giant cells (GIANT CELLS, FOREIGN-BODY), usually surrounded by lymphocytes.	Foreign-Body Granuloma,Foreign Body Granuloma,Foreign-Body Granulomas,Granuloma, Foreign Body,Granulomas, Foreign-Body
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D017438	Bisphenol A-Glycidyl Methacrylate	The reaction product of bisphenol A and glycidyl methacrylate that undergoes polymerization when exposed to ultraviolet light or mixed with a catalyst. It is used as a bond implant material and as the resin component of dental sealants and composite restorative materials.	Bis-GMA,Bis-GMA Polymer,2-Propenoic acid, 2-methyl-, (1-methylethylidene)bis(4,1-phenyleneoxy(2-hydroxy-3,1-propanediyl)) ester, homopolymer,Adaptic,Bis(Phenol A-Glycidyl Methacrylate),Bis(Phenol A-Glycidyl Methacrylate), Homopolymer,Bis(Phenol A-Glycydyl Methacrylate),Bis-GMA Resin,Bisphenol A-Glycidyl Methacrylate Homopolymer,Bisphenol A-Glycidyl Methacrylate Polymer,Concise Composite Resin,Concise Enamel Bond,Concise Enamel Bond System,Concise Resin,Concise White Sealant,Conclude Composite Resin,Conclude Resin,Delton,Epoxylite-9075,Kerr Pit and Fissure Sealant,Kerr Sealer,Nuva-Seal,Panavia Opaque,Poly(Bis-GMA),Retroplast,Silux,Bis GMA,Bis GMA Polymer,Bis GMA Resin,Bis-GMA Polymers,Bis-GMA Resins,Bisphenol A Glycidyl Methacrylate,Bisphenol A Glycidyl Methacrylate Homopolymer,Bisphenol A Glycidyl Methacrylate Polymer,Bond, Concise Enamel,Composite Resin, Concise,Composite Resin, Conclude,Composite Resins, Concise,Concise Composite Resins,Concise Resins,Enamel Bond, Concise,Epoxylite 9075,Epoxylite9075,Methacrylate, Bisphenol A-Glycidyl,Nuva Seal,NuvaSeal,Opaque, Panavia,Polymer, Bis-GMA,Polymers, Bis-GMA,Resin, Bis-GMA,Resin, Concise,Resin, Concise Composite,Resin, Conclude,Resin, Conclude Composite,Resins, Bis-GMA,Resins, Concise,Resins, Concise Composite
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus