-transparent.png){kind=logo}
SHR (spontaneously hypertensive rat) is the most popular genetic hypertensive model rat. Using the F2 progeny obtained from SHR and normotensive rats, for example, WKY (Wistar-Kyoto rat), many cosegregation studies to find the genes responsible for blood pressure have been done. In this review, we present some studies using F2 rats concerning candidate genes, renin, kallikrein, sodium potassium-ATPase, heat shock protein 70, angiotensin converting enzyme, phospholipase C-delta 1 and SA gene to show whether these genes really associate with blood pressure. We discuss the signification of these genes in the process of producing SHR and stroke-prone SHR from WKY. We hope these studies will lead to identify the mechanism of human essential hypertension.
T Katsuya, and
T Ogihara
September 1983,
Behavioral and neural biology,
T Katsuya, and
T Ogihara
August 1973,
Clinical science and molecular medicine. Supplement,
T Katsuya, and
T Ogihara
July 1996,
The Journal of clinical investigation,
T Katsuya, and
T Ogihara
May 1973,
Japanese circulation journal,
T Katsuya, and
T Ogihara
January 1972,
Nihon rinsho. Japanese journal of clinical medicine,
T Katsuya, and
T Ogihara
January 1988,
Clinical and experimental hypertension. Part A, Theory and practice,
T Katsuya, and
T Ogihara
December 2003,
Clinical and experimental pharmacology & physiology,
T Katsuya, and
T Ogihara
August 1966,
Saishin igaku. Modern medicine,
T Katsuya, and
T Ogihara
January 1986,
Advances in experimental medicine and biology,
